PERIPHERAL NEUROPATHY IN MUTANT DIABETIC MOUSE [C57BL-KS(DB-DB)]
PERIPHERAL NEUROPATHY IN MUTANT DIABETIC MOUSE [C57BL-KS(DB-DB)]
复制标题
DOI：
10.1007/bf00689757
复制
发表时间：
1978-01-01
影响因子：
12.7
通讯作者：
ROBERTSON, DM
中科院分区：
文献类型：
--
作者：
SIMA, AAF;ROBERTSON, DM
为研究糖尿病神经病变提供了一种新的动物模型。小鼠品系C57BL/Ks的纯合子(db/db)表现为严重的糖尿病伴长期高血糖。电生理检查显示运动神经传导速度严重减慢。用不同水平的EM对感觉神经和运动神经进行形态计量学检查，发现没有大的有髓纤维，形态特征提示轴突萎缩。
A new animal model for the study of diabetic neuropathy was presented. The homozygote (db/db) of the mouse strain C57BL/Ks showed severe diabetes with longstanding hyperglycemia. Electrophysiological studies showed severely decreased motor nerve conduction velocity. Morphometric examination of sensory and motor nerves by EM at different levels revealed absence of large myelinated fibers, with morphological features indicative of axonal atrophy.