Cell-cell and cell-matrix interactions.
Cell-cell and cell-matrix interactions.
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DOI：
10.1091/mbc.e13-11-0671
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发表时间：
2014-03
影响因子：
3.3
通讯作者：
Horne-Badovinac S
中科院分区：
文献类型：
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作者：
Horne-Badovinac S
肠上皮细胞在其顶端表面形成微绒毛刷状缘，介导营养吸收和宿主防御。Scott Crawley（Tyska实验室，范德比尔特大学医学中心）表明，刷状缘组装是由原钙粘蛋白-24和邻近微绒毛尖端的粘蛋白样原钙粘蛋白之间的反式相互作用驱动的。这种粘附复合物的丢失导致这些突起的长度和间距不规则，并导致在Usher综合征小鼠模型中观察到的肠道病理学。细胞与它们的邻居相互作用两个演讲使用果蝇细胞来研究细胞与细胞融合和细胞与细胞排斥的看似相反的行为。细胞-细胞融合在发育过程中很常见，包括卵子和精子的结合以及多核肌纤维的形成。约翰霍普金斯大学医学院的伊丽莎白·陈（Elizabeth Chen）指出，“攻击”细胞利用类似于豆荚体的投射穿透其靶细胞。有趣的是，在接触点处，podosomes增加靶细胞内的肌球蛋白依赖性皮质张力。减少这种张力会破坏细胞间的融合，即使足状体侵入得更远。相反，Andrei Luchici（Stramer实验室，国王学院，伦敦）研究了
Intracellular interactions shape cells Intestinal epithelial cells build a brush border of microvilli at their apical surfaces that mediates nutrient absorption and host defense. Scott Crawley (Tyska Laboratory, Vanderbilt University Medical Center) showed that brush border assembly is driven by trans interactions between protocadherin-24 and mucin-like protocadherin at the tips of adjacent microvilli. Loss of this adhesive complex causes irregularities in the length and spacing of these protrusions and contributes to the intestinal pathology seen in a mouse model of Usher syndrome.Cells interact with their neighbors Two talks used Drosophila cells to investigate the seemingly opposite behaviors of cell–cell fusion and cell–cell repulsion. Cell–cell fusions are common during development and include the union of egg and sperm and the formation of multinucleate muscle fibers. Elizabeth Chen (Johns Hopkins University School of Medicine) showed that an “attacking” cell penetrates its target cell using podosome-like projections. Interestingly, podosomes increase the myosin-dependent cortical tension within the target cell at the point of contact. Reducing this tension disrupts cell–cell fusion, even though the podosome invades farther. In contrast, Andrei Luchici (Stramer Laboratory, King’s College, London) investigated the