Origin of DNA helical structure and its sequence dependence.
Origin of DNA helical structure and its sequence dependence.
复制标题
DNA螺旋结构的起源及其序列依赖性。
DOI：
10.1021/bi00422a030
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
Jernigan,RL
中科院分区：
文献类型：
--
作者：
Sarai,A;Mazur,J;Nussinov,R;Jernigan,RL
修订稿于 1988 年 7 月 7 日收到摘要：DNA 的构象分析表明 B 型双螺旋的起源在很大程度上可归因于碱基对中的原子电荷模式。电荷模式有利于碱基对的特定螺旋堆叠。单独的碱基对（没有主链）具有形成螺旋的强烈倾向，表明主链在确定 DNA 的基本螺旋结构中发挥着相当被动的作用。主要是由碱基对上的电荷模式决定的静电相互作用稳定了特定的螺旋构象。碱基对中的电荷模式似乎是造成 DNA 构象的大部分序列依赖性的原因，而不是空间冲突。
Revised Manuscript Received July 7, 1988 abstract: Conformational analysis of DNA shows that the origin of the B-form double helix can be attributed in large part to the atomic charge pattern in the base pairs. The charge patterns favor specific helical stacking of the base pairs. Base pairs alone—without backbones—have a strong tendency to form helix, indicating that the backbones play a rather passive rolein determining the basic helical structure of DNA. It is mainly the electrostatic interactions determined by the charge pattern on base pairs that stabilize a particular helical conformation. Thecharge pattern in the base pairs appears to be responsible for much of the sequence dependence of DNA conformation, ratherthan steric clashes.