Backtracking to the future: unraveling the origins of childhood leukemia.
Backtracking to the future: unraveling the origins of childhood leukemia.
复制标题
回溯未来：揭开儿童白血病的起源。
DOI：
10.1038/s41375-023-02111-8
复制
发表时间：
2024
期刊：
影响因子：
11.4
通讯作者：
De Smith AJ
中科院分区：
文献类型：
--
作者：
De Smith AJ
Leukemia is the most common type of childhood malignancy, with~ 40 cases of acute lymphoblastic leukemia (ALL) and~ 8 cases of acute myeloid leukemia (AML) diagnosed per million children< 15 years of age in the United States [1]. For ALL, a peak in incidence in children between 2 to 5 years of age has been linked to dysregulated immune development including delayed exposure to infections during early childhood [2]. Childhood AML incidence peaks during the first two years of life, with likely distinct etiologies to ALL. Childhood ALL cure rates are> 90% in high-income countries, but survivors face life-long treatmentrelated morbidities [3]. For childhood AML, cure rates are inferior at~ 70%, and patients who survive endure similar late effects of treatment and a reduced quality of life. Thus, prevention of childhood leukemia (CL) remains an essential goal to reduce this significant health burden and requires a better understanding of CL etiologies. Given the young age-at-diagnosis of most patients, a prenatal origin for CL has long been proposed and, indeed, confirmed for several subtypes (see below, and Fig. 1). Here, we give an overview of current knowledge on the early-life origins of CL and present our efforts to elucidate this through the ReCord Study.
