Hyperuricemia in type 2 diabetic model KK-A(y)/Ta mice: a potent animal model with positive correlation between insulin resistance and plasma high uric acid levels.
Hyperuricemia in type 2 diabetic model KK-A(y)/Ta mice: a potent animal model with positive correlation between insulin resistance and plasma high uric acid levels.
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DOI：
10.1186/s13104-017-2897-x
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发表时间：
2017-11-07
影响因子：
1.8
通讯作者：
Yagasaki K
中科院分区：
文献类型：
--
作者：
Adachi SI;Yoshizawa F;Yagasaki K
高尿酸血症被认为是痛风的主要原因。越来越多的临床证据表明，高尿酸血症与胰岛素抵抗和糖代谢异常密切相关。然而，似乎还没有合适的动物模型来研究这种联系。理想的动物模型被认为是高尿酸血症和糖尿病。选择KK-Ay/Ta小鼠模型，研究高尿酸血症与胰岛素抵抗之间的关系，以描述这种动物模型的特征。雄性2型糖尿病KK-Ay/Ta小鼠和年龄匹配的正常C57BL/6J小鼠以基础20%酪蛋白饲料饲养35天。KK-Ay/Ta小鼠的摄食量、体重增加、血尿酸、血糖、胰岛素水平、胰岛素抵抗稳态模型评估(HOMA-IR)和甘油三酯水平均显著高于正常小鼠。血尿酸水平与血糖、胰岛素、HOMA-IR、甘油三酯水平呈显著正相关。这些结果表明，KK-Ay/Ta小鼠品系可用于研究高尿酸血症与胰岛素抵抗的相关性，以及食物及其成分对高尿酸血症与胰岛素抵抗关系的影响。
Hyperuricemia is recognized as a main cause of gout. Accumulating clinical evidence suggests that hyperuricemia is strongly associated with insulin resistance and abnormal glucose metabolism. However, there seem no proper animal models for investigating such associations. Ideal animal model is considered to be hyperuricemic as well as diabetic. Selecting the KK-Ay/Ta mouse model, the relationship between hyperuricemia and insulin resistance has been studied to characterize such an animal model. Male type 2 diabetic KK-Ay/Ta and age-matched normal C57BL/6J mice were maintained on a basal 20% casein diet for 35 days. Food intake, body weight gain, levels of plasma uric acid, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and triglyceride in KK-Ay/Ta mice were significantly higher than those in normal mice. Plasma uric acid levels showed significant positive correlations with plasma glucose, insulin, HOMA-IR and triglyceride levels. These results suggest that the KK-Ay/Ta mouse strain is useful for studies on correlation between hyperuricemia and insulin resistance, and for those on effects of foods and their components on the relations.