Mechanical strength evaluation of crystalline poly(L-lactic acid) fabricated by replica micromolding for bioabsorbable microneedle devices
Mechanical strength evaluation of crystalline poly(L-lactic acid) fabricated by replica micromolding for bioabsorbable microneedle devices
复制标题
DOI：
10.7567/1347-4065/ab0ff6
复制
发表时间：
2019-05
影响因子：
1.5
通讯作者：
Yukihiro Kanda;H. Takehara;T. Ichiki
中科院分区：
文献类型：
--
作者：
Yukihiro Kanda;H. Takehara;T. Ichiki
在生物医学微器件的开发中，材料性能是满足特定应用需求的关键。在这里，我们开发了一种由生物可吸收聚合物聚乳酸（PLLA）制成的微针装置的制造方法。该器件具有宽500 μm，长2 mm的高纵横比特征，并采用真空辅助微成型。此外，还研究了不同工艺条件下微针的材料性能。使用x射线衍射分析评估结晶度，并使用新开发的微模压亚毫米样品的显微三点弯曲测试装置确定机械强度。这些关于制造工艺和材料性能的信息是聚合物微器件发展的重要指导原则。
In the development of biomedical microdevices, material properties are the key to fulfilling specific application requirements. Here, we developed a fabrication method for a microneedle device made of the bioabsorbable polymer poly(L-lactic acid) (PLLA). The device has a high aspect ratio feature of 500 μm in width and 2 mm in length and uses vacuum-assisted micromolding. In addition, the material properties of the microneedles were investigated under different process conditions. Crystallinity was evaluated using X-ray diffraction analysis, and mechanical strength was determined using a newly developed microscopic three-point bending test apparatus for micromolded sub-millimeter samples. This information about fabrication processes and material properties is an important guiding principle for the development of polymer microdevices.