Replacement of intervertebral discs in chimpanzees by silicone-dacron implants: a preliminary report.
Replacement of intervertebral discs in chimpanzees by silicone-dacron implants: a preliminary report.
复制标题
用硅酮涤纶植入物替代黑猩猩的椎间盘：初步报告。
DOI：
--
复制
发表时间：
1973
期刊：
影响因子：
--
通讯作者：
Jay E. Hopkins
中科院分区：
文献类型：
--
作者：
J. Urbaniak;D. Bright;Jay E. Hopkins
我们已经开发出一种椎间盘假体替代品。尽管目前对退行性椎间盘疾病患者的治疗通常是有效的，但在永久性疼痛缓解方面确实存在某些不足。大多数持续性症状似乎是由于椎体沉降和随后的后关节不协调以及关节炎变化而发生的。从理论上讲，在发生不可挽回的变化之前，用椎间融合器置换患病的椎间盘将保持解剖学上的一致性和生理功能。本研究是硅橡胶-涤纶假体的研制及其在黑猩猩体内实验的初步报告。我们的早期评估表明，假体允许运动，保持椎间隙，并吸收施加在脊柱上的压缩应力。人工椎间盘具有与正常黑猩猩椎间盘相当的生物力学行为。邻近骨吸收、反应性骨形成和感染是我们经历过的并发症。继续评价是必要的。
We have developed a prosthetic replacement for the intervertebral disc. Although current management of a patient with degenerative disc disease is usually effective, certain inadequacies in permanent pain relief do exist. Most of the persistent symptoms seem to occur because of vertebral settling with subsequent posterior joint incongruities followed by arthritic changes. Theoretically, the replacement of a diseased intervertebral disc, prior to the onset of irrevocable changes, with a spacer would maintain anatomical congruity and physiologic function. This study is the preliminary report of the development of a silicone-Dacron prosthesis and its experimental trials in chimpanzees. Our early evaluation shows that the prosthesis allows motion, maintains the intervertebral space, and absorbs the compressive stresses placed on the spine. The artificial disc has a biomechanical behavior comparable to the normal chimp disc. Resorption of adjacent bone, reactive bone formation, and infection are complications that we have experienced. Continued evaluation is necessary.