A comprehensive experimental study on material properties of human brain tissue
A comprehensive experimental study on material properties of human brain tissue
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DOI：
10.1016/j.jbiomech.2013.09.001
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发表时间：
2013-11-15
影响因子：
2.4
通讯作者：
Yang, King H.
中科院分区：
文献类型：
--
作者：
Jin, Xin;Zhu, Feng;Yang, King H.
对脑组织的生物力学响应进行全面的研究是探讨创伤性脑损伤机制的必要条件。已发表的脑材料性质的研究大多是在特定类型的负载下进行的，这是不够的，以开发准确的脑组织本构方程。此外，不一致或矛盾的数据在文献中的计算模型开发人员不可能创建一个单一的大脑材料模型，可以适合大多数，如果不是全部，实验结果。在目前的研究中，共240个脑组织标本进行了测试下的拉伸（n= 72），压缩（n = 72），剪切（n=96）加载模式在不同的应变率。研究了脑组织的灰白色物质差异、区域差异和白色物质内部的方向差异，得到了50%工程应变下的应力-应变关系。在所有三种加载模式下观察到应变率依赖性。白色物质在压缩和剪切时比灰质硬。放射冠在拉伸和压缩时比皮质、丘脑和胼胝体更硬。在剪切载荷下观察到白色物质的方向依赖性。(C)2013爱思唯尔有限公司保留所有权利。
A comprehensive study on the biomechanical response of human brain tissue is necessary to investigate traumatic brain injury mechanisms. Published brain material property studies have been mostly performed under a specific type of loading, which is insufficient to develop accurate brain tissue constitutive equations. In addition, inconsistent or contradictory data in the literature made it impossible for computational model developers to create a single brain material model that can fit most, if not all, experimental results.In the current study, a total of 240 brain tissue specimens were tested under tension (n=72), compression (n=72), and shear (n=96) loading modes at varying strain rates. Gray-white matter difference, regional difference, and directional difference within white matter were also investigated.Stress-strain relationships of human brain tissue were obtained up to 50% of engineering strain. Strain rate dependency was observed under all three loading modes. White matter was stiffer than gray matter in compression and shear. Corona radiata was found to be stiffer than cortex, thalamus, and corpus callosum in tension and compression. Directional dependency of white matter was observed under shear loading. (C) 2013 Elsevier Ltd. All rights reserved.