Ambient Air Pollution and the Risk of Stillbirth
Ambient Air Pollution and the Risk of Stillbirth
复制标题
DOI：
10.1093/aje/kws029
复制
发表时间：
2012-08-15
影响因子：
5
通讯作者：
Rich, David Q.
中科院分区：
文献类型：
--
作者：
Faiz, Ambarina S.;Rhoads, George G.;Rich, David Q.
本研究的目的是检查死产的风险与怀孕期间的环境空气污染。研究人员利用1998年至2004年新泽西的活产和胎儿死亡数据，将每天的空气污染浓度分配给每个出生或胎儿死亡。广义估计方程模型被用来估计死产的相对几率与四分位数范围内的平均空气污染物浓度的增加，在第一，第二，第三孕期和整个怀孕。在孕早期，平均二氧化氮浓度每增加10-ppb，死产的相对几率显著增加（比值比（OR）1.16，95置信区间（CI）：1.03，1.31），在第一个平均二氧化硫浓度每增加3-ppb，（OR 1.13，95 CI：1.01，1.28）和第三组（OR 1.26，95 CI：1.03，1.37）妊娠期，第二个妊娠期平均一氧化碳浓度每增加0.4 ppm（OR 1.14，95 CI：1.01，1.28）和第三个（OR 1.14，95 CI：1.06，1.24）妊娠期。虽然怀孕期间的环境空气污染似乎增加了死胎的相对几率，但需要进一步的研究来证实这些发现并检查机械解释。
The purpose of the present study was to examine the risk of stillbirth associated with ambient air pollution during pregnancy. Using live birth and fetal death data from New Jersey from 1998 to 2004, the authors assigned daily concentrations of air pollution to each birth or fetal death. Generalized estimating equation models were used to estimate the relative odds of stillbirth associated with interquartile range increases in mean air pollutant concentrations in the first, second, and third trimesters and throughout the entire pregnancy. The relative odds of stillbirth were significantly increased with each 10-ppb increase in mean nitrogen dioxide concentration in the first trimester (odds ratio (OR) 1.16, 95 confidence interval (CI): 1.03, 1.31), each 3-ppb increase in mean sulfur dioxide concentration in the first (OR 1.13, 95 CI: 1.01, 1.28) and third (OR 1.26, 95 CI: 1.03, 1.37) trimesters, and each 0.4-ppm increase in mean carbon monoxide concentration in the second (OR 1.14, 95 CI: 1.01, 1.28) and third (OR 1.14, 95 CI: 1.06, 1.24) trimesters. Although ambient air pollution during pregnancy appeared to increase the relative odds of stillbirth, further studies are needed to confirm these findings and examine mechanistic explanations.