Opposite effect of negative and positive affect on stress procoagulant reactivity
Opposite effect of negative and positive affect on stress procoagulant reactivity
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DOI：
10.1016/j.physbeh.2005.06.005
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发表时间：
2005-09-15
影响因子：
2.9
通讯作者：
Fischer, JE
中科院分区：
文献类型：
--
作者：
von K채nel, R;Kudielka, BM;Fischer, JE
急性心理应激时过度的促凝血反应可能导致冠状动脉血栓形成，持续的低水平全身凝血激活可能与冠状动脉疾病的发生发展有关。我们调查了消极和积极的情感和感知的社会支持是否会缓和应激促凝血剂的反应性。对27名看似健康的男性(平均年龄47.8岁)进行了心理功能、疲惫、负性情感、抑郁、焦虑、担忧、活力和社会支持的评估，他们接受了13分钟的Trier社会压力测试，其中包括准备、演讲和心算。测定应激前后血浆von Willebrand因子抗原(VWF：Ag)、纤维蛋白原、凝血因子VII活性(FVII：C)、FVIII：C、FXII：C和D-二聚体水平。急性应激引起血流动力学、皮质醇和凝血活性显著增加(p值和lt；0.05)。VWF：Ag反应性与疲惫(r=-0.63，p<；0.001)、负性情感(r=-0.53，p=0.005)、忧虑(r=-0.53，p=0.005)呈负相关。精疲力竭和负性情感是VWF：AG反应性的独立预测因子，可解释其54%的变异。纤维蛋白原反应性与负性情感(r=-0.59，p=0.002)和焦虑(r=-0.54，p=0.005)呈负相关；负性情感是纤维蛋白原反应性的独立预测因子，可解释其35%的变异。心理功能与Fvii：C反应性也相关(r=-0.52，p=0.006)。FVIII：C反应性与积极情绪呈正相关(r=0.48，p=0.012)，而社会支持与促凝血反应性的正相关未达显著水平。消极情绪与对压力的促凝剂反应减弱有关，而积极情绪则与之相反。负面情绪不太可能增强健康男性的急性促凝血应激反应。(C)2005 Elsevier B.V.保留所有权利。
Exaggerated procoagulant responses to acute mental stress may contribute to coronary thrombosis, and continuing low-grade systemic coagulation activation may link negative affect with the development of coronary artery disease. We investigated whether negative and positive affect and perceived social support would moderate stress procoagulant reactivity. Psychological functioning, exhaustion, negative affectivity, depression, anxiety, worrying, vigor, and social support were assessed in 27 apparently healthy men (mean age 47 8 years) who under-went the 13-min Trier Social Stress Test combining preparation, speech, and mental arithmetic. Plasma levels of von Willebrand factor antigen (VWF:Ag), fibrinogen, factor VII clotting activity (FVII:C), FVIII:C, FXII:C, and D-dimer were measured immediately before and after stress. Acute stress elicited significant increases in hemodynamic, cortisol, and coagulant activity (p values < 0.05). VWF:Ag reactivity showed inverse relationships with exhaustion (r=-0.63, p < 0.001), negative affectivity (r=-0.53, p=0.005), and worrying (r=-0.53, p=0.005). Exhaustion and negative affectivity emerged as independent predictors of VWF:Ag reactivity explaining 54% of its variance. Fibrinogen reactivity showed inverse relationships with negative affectivity (r=-0.59, p=0.002) and anxiety (r=-0.54, p=0.005); negative affectivity emerged as an independent predictor of fibrinogen reactivity explaining 35% of its variance. Psychological functioning and FVII:C reactivity were also correlated (r=-0.52, p=0.006). Whereas FVIII:C reactivity correlated positively with vigorous mood (r=0.48,p=0.012), positive associations between social support and procoagulant reactivity did not reach significance. Negative affect was associated with attenuated procoagulant reactivity to stress and the opposite was observed for positive affect. Negative affect is not likely to enhance the acute procoagulant stress response in healthy men. (c) 2005 Elsevier B.V. All rights reserved.