Arterial Stiffness and Wave Reflections in Relation to Plasma Advanced Glycation End Products in a Chinese Population
Arterial Stiffness and Wave Reflections in Relation to Plasma Advanced Glycation End Products in a Chinese Population
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中国人群的动脉僵硬度和波反射与血浆晚期糖基化终产物的关系
DOI：
10.1093/ajh/hpt014
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发表时间：
2013-06-01
影响因子：
3.2
通讯作者：
Wang, Ji-Guang
中科院分区：
文献类型：
--
作者：
Huang, Qi-Fang;Sheng, Chang-Sheng;Wang, Ji-Guang
BACKGROUNDAccumulation of advanced glycation end products (AGEs) in the human body might engender arterial stiffening. We investigated the relationship of plasma AGE concentration with arterial stiffness and wave reflections in a Chinese population.METHODSThe study subjects were recruited from a newly established residential area in the suburb of Shanghai in 2009. Using the SphygmoCor system, we measured carotid-femoral pulse wave velocity (cfPWV) and central augmentation indices (cAI) and peripheral augmentation indices (pAI). Plasma AGE concentration was measured by the enzyme-linked immunosorbent assay method and logarithmically transformed for statistical analysis.RESULTSThe 1,051 study participants (mean age = 55.1 +/- 13.1 years) included 663 (63.1%) women, 390 (37.1%) hypertensive patients, and 90 (8.6%) diabetic or prediabetic subjects. Plasma AGE concentration was higher in men than women (5.62 vs. 5.07 mu g/ml; P = 0.02) and with older age (r = 0.13 in both sexes; P
