PREVENTION OF VIRUS-INDUCED NEOPLASMS IN MICE THROUGH PASSIVE TRANSFER OF IMMUNITY BY SENSITIZED SYNGENEIC LYMPHOID CELLS
PREVENTION OF VIRUS-INDUCED NEOPLASMS IN MICE THROUGH PASSIVE TRANSFER OF IMMUNITY BY SENSITIZED SYNGENEIC LYMPHOID CELLS
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DOI：
10.1073/pnas.57.4.1068
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发表时间：
1967-01-01
影响因子：
11.1
通讯作者：
LECKBAND, E
中科院分区：
文献类型：
--
作者：
LAW, LW;TING, RC;LECKBAND, E
通过过继获得性免疫完全预防了多瘤病毒诱导的C57BL小鼠肿瘤的发生。如果直到病毒感染后30天才给药，静脉接种致敏淋巴样细胞是有效的。致敏的同种异体淋巴样细胞、杀死的同种异体细胞和来自高免供者的血清均无效。肿瘤和宿主的抗原性差异可以用来控制原发肿瘤。通过同种移植物类型的免疫反应，消除由病毒诱导的、含有tr[移植抵抗]/抗原的肿瘤细胞的克隆。
Polyoma virus-induced neoplasms in C57BL strain mice were totally prevented through adoptively acquired immunity. Sensitized lymphoid cells inoculated intravenously were effective if administered as late as 30 days after virus infection. Sensitized allogeneic lymphoid cells, killed syngeneic cells, and serum from hyperimmunized donors were ineffective. The antigenic difference between tumor and host can be used to control primary tumors. Clones of neoplastic cells induced by virus and containing TR [trans-plantation-resistance]/antigen are eliminated by an immune reaction of the homograft type.