Vascular risk factors, ApoE ε4 allele, and gender and the risk of Alzheimer's disease:: Perspectives on prevention
Vascular risk factors, ApoE ε4 allele, and gender and the risk of Alzheimer's disease:: Perspectives on prevention
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DOI：
10.1002/ddr.10064
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发表时间：
2002-06-01
影响因子：
3.8
通讯作者：
Tuomilehto, J
中科院分区：
文献类型：
--
作者：
Kivipelto, M;Helkala, EL;Tuomilehto, J
这篇综述总结了我们最近在一项基于人群的前瞻性研究中的主要发现，该研究调查了中年血压 (BP) 和胆固醇值升高作为老年痴呆症 (AD) 和轻度认知障碍 (MCI) 的危险因素。此外，我们还提供了一些关于 AD 危险因素概况中性别相关差异的新数据。我们的结果表明，血管危险因素对于男女 AD 的发展都很重要，但 AD 危险因素概况可能存在一些与性别相关的差异。我们的研究结果还表明，不同的环境因素（例如抗高血压药物治疗）可能会改变载脂蛋白 E epsilon4 等位基因在 AD 发展中的作用。这些数据强调了有效一级预防和早期治疗高血压和高胆固醇血症的重要性，作为降低 AD 风险的潜在途径。 (C) 2002 Wiley-Liss, Inc.
This review summarizes the main findings from our recent research within the prospective, population-based study investigating midlife elevated blood pressure (BP) and cholesterol values as risk factors for Alzheimer's disease (AD) and mild cognitive impairment (MCI) later in life. Furthermore, we present some new data on the gender-related differences in the risk factor profiles for AD. Our results suggest that vascular risk factors are important for the development of AD in both genders, but some gender-related differences in the risk factors profiles for AD may exist. Our findings also suggest that different environmental factors such as anti hypertensive drug treatment may modify the effect of apolipoprotein E epsilon4 allele in the development of AD. These data emphasize the importance of effective primary prevention and early treatment of hypertension and hypercholesterolemia as potential avenues for reducing the risk of AD. (C) 2002 Wiley-Liss, Inc.