Enantioselective Diels?Alder Reaction of 3-Nitrocoumarins Promoted by Chiral Organoammonium Salt Catalysts
Enantioselective Diels?Alder Reaction of 3-Nitrocoumarins Promoted by Chiral Organoammonium Salt Catalysts
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手性有机铵盐催化剂促进3-硝基香豆素的对映选择性Diels?Alder反应
DOI：
10.1055/s-0040-1707302
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发表时间：
2020
期刊：
影响因子：
2
通讯作者：
Mizoguchi Haruki
中科院分区：
文献类型：
--
作者：
Sakakura Akira;Fujii Yudai;Nakao Ryota;Sugihara Saki;Fujita Keita;Araki Yuya;Kudoh Takayuki;Hayakawa Ichiro;Mizoguchi Haruki
研究了3-硝基香豆素对映选择性Diels-Alder反应。色氨酸衍生的dc1对称型硫脲有机铵催化剂促进了3-硝基香豆素与丹尼舍夫斯基二烯的反应，得到相应的加合物，具有良好的对映选择性（ee达94%）。其中一种加合物转化为手性碳环季β-氨基醇。
An enantioselective Diels–Alder reaction of 3-nitrocoumarins has been developed. A tryptophan-derivedC1-symmetric organoammonium thiourea catalyst promoted the reaction of 3-nitrocoumarins with Danishefsky’s diene to give the corresponding adducts with good enantioselectivity (up to 94% ee). One of the resulting adducts was converted into a chiral carbocyclic quaternary β-amino alcohol.