Trajectories and predictors of symptom occurrence, severity, and distress in prostate cancer patients undergoing radiation therapy.
Trajectories and predictors of symptom occurrence, severity, and distress in prostate cancer patients undergoing radiation therapy.
复制标题
接受放射治疗的前列腺癌患者症状发生、严重程度和痛苦的轨迹和预测因素。
DOI：
10.1016/j.jpainsymman.2011.10.020
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发表时间：
2012
影响因子：
4.7
通讯作者：
Miaskowski,Christine
中科院分区：
文献类型：
--
作者：
Knapp,Katie;Cooper,Bruce;Koetters,Theresa;Cataldo,Janine;Dhruva,Anand;Paul,StevenM;West,Claudia;Aouizerat,BradleyE;Miaskowski,Christine
放射治疗（RT）是前列腺癌的一种常用治疗方法.尽管有可用的研究，前列腺癌患者报告说，有关副作用的信息是他们最重要的未满足的需求。额外的研究是需要的，侧重于具体方面的病人的症状experience.METHODS研究的目的是评估的轨迹的发生，严重程度，和痛苦的六个最普遍的症状报告的病人接受RT前列腺癌和影响选定的人口统计学和临床特征对这些trajectors.METHODS患者完成了纪念症状评估量表11次之前，对于排尿、疼痛、缺乏能量、感觉困倦、睡眠困难和腹泻等问题，使用多水平广义线性模型评估其发生、严重程度和痛苦的轨迹。排尿和腹泻的问题表现出更复杂的模式的变化随着时间的推移。CONCLUSIONAlthough纵向数据疼痛，缺乏能源，感觉昏昏欲睡，难以入睡是有限的，他们是非常普遍的症状，在这些患者。此外，腹泻成为这些患者在RT过程中的一个重要问题。一些人口统计学和临床特征差异影响这些常见症状的轨迹。
CONTEXTRadiation therapy (RT) is a common treatment for prostate cancer. Despite available research, prostate cancer patients report that information about side effects is their most important unmet need. Additional research is needed that focuses on specific dimensions of the patient's symptom experience.OBJECTIVESThe study's purposes were to evaluate the trajectories of occurrence, severity, and distress of the six most prevalent symptoms reported by patients undergoing RT for prostate cancer and the effects of selected demographic and clinical characteristics on these trajectories.METHODSPatients completed the Memorial Symptom Assessment Scale 11 times before, during, and after RT. For problems with urination, pain, lack of energy, feeling drowsy, difficulty sleeping, and diarrhea, the trajectories of occurrence, severity, and distress were evaluated using multilevel generalized linear models.RESULTSAcross all three dimensions, pain, lack of energy, feeling drowsy, and difficulty sleeping followed a decreasing linear trend. Problems with urination and diarrhea demonstrated more complex patterns of change over time.CONCLUSIONAlthough longitudinal data on pain, lack of energy, feeling drowsy, and difficulty sleeping are limited, they are highly prevalent symptoms in these patients. In addition, diarrhea becomes a significant problem for these patients over the course of RT. A number of demographic and clinical characteristics affect the trajectories of these common symptoms differentially.