Multi-compartment linear noise approximation
Multi-compartment linear noise approximation
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DOI：
10.1088/1742-5468/2012/11/p11010
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发表时间：
2012-11-01
影响因子：
2.4
通讯作者：
Pahle, Juergen
中科院分区：
文献类型：
--
作者：
Challenger, Joseph D.;McKane, Alan J.;Pahle, Juergen
量化生物化学和其他系统中存在的随机波动的能力变得越来越重要。这些波动的分析描述是有吸引力的，因为随机模拟是计算昂贵的。建立在以前的工作，线性噪声近似的生化模型与许多隔间，例如细胞。然后在软件包COPASI中实现该过程。这种技术说明了两个简单的例子，然后应用到一个更现实的生化模型。噪声的表达式，给出的形式的协方差矩阵，。
The ability to quantify the stochastic fluctuations present in biochemical and other systems is becoming increasing important. Analytical descriptions of these fluctuations are attractive, as stochastic simulations are computationally expensive. Building on previous work, a linear noise approximation is developed for biochemical models with many compartments, for example cells. The procedure is then implemented in the software package COPASI. This technique is illustrated with two simple examples and is then applied to a more realistic biochemical model. Expressions for the noise, given in the form of covariance matrices, are presented.