bantam miRNA Promotes Systemic Growth by Connecting Insulin Signaling and Ecdysone Production
bantam miRNA Promotes Systemic Growth by Connecting Insulin Signaling and Ecdysone Production
复制标题
DOI：
10.1016/j.cub.2013.01.072
复制
发表时间：
2013-03-18
期刊：
影响因子：
9.2
通讯作者：
Milan, Marco
中科院分区：
文献类型：
--
作者：
Boulan, Laura;Martin, David;Milan, Marco
在多细胞生物体的发育过程中，身体的生长在生物体的尺度上受到长距离信号分子（主要是激素）的活动的控制。这些系统性因素协调发育组织之间的生长，并作为中继来调节身体生长以应对环境变化[1]。在靶器官中，远程信号与组织自主信号协同作用，以调节给定组织的最终大小。在果蝇中，类固醇激素蜕皮激素起着双重作用：分泌高峰促进发育过渡和成熟，而基础生产负控制生长速度。蜕皮激素的拮抗作用和保守的胰岛素/胰岛素生长因子（IGF）信号传导途径调节全身生长并调节最终体型[2，3]。在这里，我们解开了一个意想不到的作用，矮脚鸡microRNA在控制果蝇的身体大小。我们的数据揭示，除了其在自主诱导组织生长中的良好表征的功能之外[4-9]，在蜕皮激素产生细胞中的bantam活性通过抑制蜕皮激素释放来促进全身生长。我们还提供了证据表明，蜕皮激素生产的调节胰岛素信号依赖于抑制矮脚鸡活动。这些结果确定了这两种激素之间串扰的分子机制，并为矮脚鸡在生长控制中的良好特征作用增加了一层新的复杂性。
During the development of multicellular organisms, body growth is controlled at the scale of the organism by the activity of long-range signaling molecules, mostly hormones. These systemic factors coordinate growth between developing tissues and act as relays to adjust body growth in response to environmental changes [1]. In target organs, long-range signals act in concert with tissue-autonomous ones to regulate the final size of a given tissue. In Drosophila, the steroid hormone ecdysone plays a dual role: peaks of secretion promote developmental transitions and maturation, while basal production negatively controls the speed of growth. The antagonistic action of ecdysone and the conserved insulin/insulin growth factor (IGF) signaling pathway regulate systemic growth and modulate final body size [2, 3]. Here we unravel an unexpected role of bantam microRNA in controlling body size in Drosophila. Our data unveil that, in addition to its well-characterized function in autonomously inducing tissue growth [4-9], bantam activity in ecdysone-producing cells promotes systemic growth by repressing ecdysone release. We also provide evidence that the regulation of ecdysone production by insulin signaling relies on the repression of bantam activity. These results identify a molecular mechanism that underlies the crosstalk between these two hormones and add a new layer of complexity to the well-characterized role of bantam in growth control.