Different physiological MRI noise between cortical layers
Different physiological MRI noise between cortical layers
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DOI：
10.1002/mrm.20229
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发表时间：
2004-10-01
影响因子：
3.3
通讯作者：
Goelman, G
中科院分区：
文献类型：
--
作者：
Pelled, G;Goelman, G
在皮层中观察到活鼠组的血氧水平依赖性（BOLD）信号的时间波动明显高于死鼠组，表明信号波动中存在生理信息。类似的分析显示视觉皮层之间的波动存在显着差异。在第 4 层和第 5 层观察到最高波动，在第 1 层观察到最低波动。考虑到与已发表的电生理学研究的一致性，预计深层（特别是第 4 层）自发活动较高，浅层活动较低，我们假设 BOLD 信号时间波动可能反映了皮质神经元活动。通过两种方式测量大鼠大脑超高空间分辨率数据的时间波动。在第一个中，根据已知的层宽度进行分析，在第二个中，选择沿着皮质的 117R 等长线。第二种方法沿着皮层产生时间波动，类似于已知的神经元密度分布，包括层内结构，特别是在第 5 层内。 (C) 2004 Wiley-Liss, Inc.
Significantly higher temporal fluctuations of the blood oxygenation level-dependent (BOLD) signal in the living rat group compared to that in the dead rat group were observed in the cortex, suggesting the existence of physiological information in the signal fluctuations. A similar analysis shows significantly different fluctuations between visual cortical layers. The highest fluctuations were observed in layers 4 and 5 and the lowest in layer 1. Given the consistency with published electrophysiology studies anticipating high spontaneous activity in the deeper layers (particularly layer 4), and low activity in superficial layers, we hypothesize that the BOLD signal temporal fluctuations may reflect cortical neuronal activity. Temporal fluctuations in ultra-high spatial resolution data of the rat brain were measured in two ways. In the first, analyses were performed according to known layer widths, and in the second equal lines of 117 R along the cortex were selected. The second approach yielded temporal fluctuations along the cortex that resemble known neuronal density distributions including the intralayer structure, particularly within layer 5. (C) 2004 Wiley-Liss, Inc.