The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota.
The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota.
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DOI：
10.1186/1471-2164-10-145
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发表时间：
2009-04-02
期刊：
影响因子：
4.4
通讯作者：
Kyrpides N
中科院分区：
文献类型：
--
作者：
Anderson IJ;Dharmarajan L;Rodriguez J;Hooper S;Porat I;Ulrich LE;Elkins JG;Mavromatis K;Sun H;Land M;Lapidus A;Lucas S;Barry K;Huber H;Zhulin IB;Whitman WB;Mukhopadhyay B;Woese C;Bristow J;Kyrpides N
海洋葡萄球菌（Staphylothermus marinus）是古菌门Crenarchaeota的一种厌氧硫还原肽发酵菌。这是第三个异养，专性硫还原crenarchaeote测序，并提供了一个机会，比较分析的三个基因组。超嗜热crenarchaeote海洋葡萄球菌（Staphylothermus marinus）的1.57 Mbp基因组已完全测序。主要的能量产生途径可能涉及2-含氧酸：铁氧还蛋白氧化还原酶和ADP形成乙酰辅酶A脱氢酶。S. marinus具有几种在其他泉古菌中不存在的酶，包括可能参与氨基酸降解的钠离子转运脱羧酶。S. marinus缺乏硫还原酶，该酶存在于已经测序的另外两种硫还原泉古菌中--悬挂的Thermofilumpendens和丁基高温菌。相反，它有三个操纵子类似于激烈火球菌的mbh和mbx操纵子，这可能在硫还原和/或氢产生中发挥作用。这两种海洋生物，S. marinus和H. butylicus比T. pendens和使用共转运体的钾吸收，而T. pendens使用ATP依赖性钾转运蛋白。T. pendens已经适应了营养丰富的环境，而H. butylicus适应于营养贫乏的环境，S.马里纳斯位于这两个极端之间。三个异养硫还原crenarchaeotes已经适应了他们的栖息地，陆地与海洋，通过他们的运输内容，他们也适应了不同水平的营养环境。尽管它们都使用硫作为电子受体，但它们可能具有不同的硫还原途径。
Staphylothermus marinus is an anaerobic, sulfur-reducing peptide fermenter of the archaeal phylum Crenarchaeota. It is the third heterotrophic, obligate sulfur reducing crenarchaeote to be sequenced and provides an opportunity for comparative analysis of the three genomes. The 1.57 Mbp genome of the hyperthermophilic crenarchaeote Staphylothermus marinus has been completely sequenced. The main energy generating pathways likely involve 2-oxoacid:ferredoxin oxidoreductases and ADP-forming acetyl-CoA synthases. S. marinus possesses several enzymes not present in other crenarchaeotes including a sodium ion-translocating decarboxylase likely to be involved in amino acid degradation. S. marinus lacks sulfur-reducing enzymes present in the other two sulfur-reducing crenarchaeotes that have been sequenced – Thermofilum pendens and Hyperthermus butylicus. Instead it has three operons similar to the mbh and mbx operons of Pyrococcus furiosus, which may play a role in sulfur reduction and/or hydrogen production. The two marine organisms, S. marinus and H. butylicus, possess more sodium-dependent transporters than T. pendens and use symporters for potassium uptake while T. pendens uses an ATP-dependent potassium transporter. T. pendens has adapted to a nutrient-rich environment while H. butylicus is adapted to a nutrient-poor environment, and S. marinus lies between these two extremes. The three heterotrophic sulfur-reducing crenarchaeotes have adapted to their habitats, terrestrial vs. marine, via their transporter content, and they have also adapted to environments with differing levels of nutrients. Despite the fact that they all use sulfur as an electron acceptor, they are likely to have different pathways for sulfur reduction.
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