Cystatin C -: A marker for assessment of the glomerular filtration rate in patients with cisplatin chemotherapy
Cystatin C -: A marker for assessment of the glomerular filtration rate in patients with cisplatin chemotherapy
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DOI：
10.1159/000092485
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发表时间：
2006-01-01
影响因子：
2.8
通讯作者：
Blaschke, S.
中科院分区：
文献类型：
--
作者：
Benoehr, P.;Grenz, A.;Blaschke, S.
背景。胱抑素 C 最近被提议作为肾小球滤过率 (GFR) 的理想标志物。在本研究中，将接受顺铂化疗的肾功能正常患者的血清胱抑素 C 水平与血清肌酐浓度和菊粉清除率进行比较，以评估胱抑素 C 作为 GFR 替代内源性标志物的有效性。方法：在临床试验中应用顺铂前后收集患者的血样，用于评估胱抑素 C、肌酐和菊粉清除率。总体而言，该研究纳入了 41 名患者，其中 35 名患者有资格在两种不同的基于顺铂的化疗方案中接受顺铂治疗。结果：应用顺铂后，安慰剂组的胱抑素 C 血清水平增加了 21%。菊粉清除率分析显示，安慰剂组患者的菊粉清除率下降了 23%。相反，通过分析血清肌酐水平无法检测到显着变化。结论：对于早期评估顺铂引起的 GFR 损伤，胱抑素 C 是比血清肌酐更敏感的临床标志物。通过菊粉清除率测量，半胱氨酸蛋白酶抑制剂 C 血清浓度的变化与 GFR 降低密切相关。版权所有 D 2006 S. Karger AG，巴塞尔
Background. Cystatin C has recently been proposed as an ideal marker for glomerular filtration rate (GFR). In this study, cystatin C serum levels were evaluated in comparison to serum creatinine concentrations and inulin clearances in patients with normal kidney function receiving cisplatin-based chemotherapy to assess the validity of cystatin C as an alternative endogenous marker of GFR. Methods: Blood samples for the assessment of cystatin C, creatinine and inulin clearances were collected in patients before and after application of cisplatin in a clinical trial. Overall, 41 patients were included in the study, 35 of them were eligible receiving cisplatin in two different cisplatin-based chemotherapy schedules. Results: A 21% increase of cystatin C serum levels was demonstrated in the placebo group after application of cisplatin. Analysis of inulin clearances revealed a 23% loss of inulin clearance in patients of the placebo arm. In contrast, significant changes could not be detected by analysis of serum creatinine levels. Conclusions: Cystatin C represents a more sensitive clinical marker than serum creatinine for the early assessment of GFR damage caused by cisplatin. Changes in cystatin C serum concentrations correlate well to GFR decrease as measured by inulin clearance. Copyright D 2006 S. Karger AG, Basel