Oligosaccharides Self-Assemble and Show Intrinsic Optical Properties
Oligosaccharides Self-Assemble and Show Intrinsic Optical Properties
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DOI：
10.1021/jacs.8b11882
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发表时间：
2019-03
影响因子：
15
通讯作者：
Yang Yu;Soeun Gim;Dongyoon Kim;Zohar A. Arnon;E. Gazit;P. Seeberger;M. Delbianco
中科院分区：
文献类型：
--
作者：
Yang Yu;Soeun Gim;Dongyoon Kim;Zohar A. Arnon;E. Gazit;P. Seeberger;M. Delbianco
自组装肽和寡核苷酸已经产生了在纳米技术中具有若干应用的合成材料。尽管天然多糖如纤维素和几丁质是生物材料的关键结构组分，但合成寡糖聚集成明确的结构还没有报道。在这里，我们报告说，六个合成寡糖，从二聚体到六聚体，自组装成不同形态的纳米结构，并在可见光谱内发射的激发依赖性的方式。链长、单体修饰和聚集方法的明确差异产生具有不同形状和性质的糖材料。在可见光谱内的宽范围内的激发依赖荧光说明了它们在光学器件和成像应用中的潜力。我们预计，我们的系统方法研究定义明确的合成寡糖将形成我们的理解碳水化合物在自然界中的相互作用的基础。
Self-assembling peptides and oligonucleotides have given rise to synthetic materials with several applications in nanotechnology. Aggregation of synthetic oligosaccharides into well-defined architectures has not been reported even though natural polysaccharides, such as cellulose and chitin, are key structural components of biomaterials. Here, we report that six synthetic oligosaccharides, ranging from dimers to hexamers, self-assemble into nanostructures of varying morphologies and emit within the visible spectrum in an excitation-dependent manner. Well-defined differences in chain length, monomer modification, and aggregation methods yield glycomaterials with distinct shapes and properties. The excitation-dependent fluorescence in a broad range within the visible spectrum illustrates their potential for use in optical devices and imaging applications. We anticipate that our systematic approach of studying well-defined synthetic oligosaccharides will form the foundation of our understanding of carbohydrate interactions in nature.