Synchronization of sacral skin blood flow oscillations in response to local heating.
Synchronization of sacral skin blood flow oscillations in response to local heating.
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DOI：
10.1109/iembs.2011.6090501
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Liao F
中科院分区：
文献类型：
--
作者：
Jan YK;Liao F
局部加热通过激活感觉轴突反射和新陈代谢一氧化氮控制，导致皮肤血流量增加。已经观察到，没有温度变化的偏远皮肤区域也显示出血流量略有增加。这种间接血管扩张的机制尚不清楚。我们假设遥远的皮肤区域将增强血流振荡(BFO)的同步性，从而诱导血管扩张反应。我们对12例健康人的两处相隔10 cm的骶部皮肤进行了BFO的研究。利用集成经验模式分解方法将血流信号分解为一组固有模式函数(IMF)，并选择IMF对BFO的肌源性、神经源性和代谢模式进行量化。然后利用希尔伯特变换计算了模式的瞬时相位。从一对特征模之间的相位差时间序列中，检测出相位同步的历元，并利用替代时间序列来估计统计意义的程度。结果表明，在最大血管扩张期，神经源性BFO之间的时相同步性明显增强。我们还观察到两个皮肤部位的肌源性BFO之间存在微弱的同步。我们的结果提示，BFO的同步性可能与非加热部位皮肤血流的变化有关。
Local heating causes an increase in skin blood flow by activating sensory axon reflex and metabolic nitric oxide controls. It has been observed that the remote skin area without temperature changes also shows a slightly increase in blood flow. The responsible mechanism of this indirect vasodilation remains unclear. We hypothesized that the remote skin area will have enhanced synchronization of blood flow oscillations (BFO), thus inducing a vasodilatory response. We studied BFO in two sites separated 10cm of the sacral skin in 12 healthy people. Ensemble empirical mode decomposition method was used to decompose blood flow signals into a set of intrinsic mode functions (IMFs), and an IMF was selected to quantify each of myogenic, neurogenic, and metabolic modes of BFO. Then the instantaneous phase of the mode was calculated using the Hilbert transform. From the time series of phase difference between a pair of characteristic modes, we detected the epochs of phase synchronization and estimated the level of statistical significance using surrogate time series. The results showed that phase synchronization between neurogenic BFO was significantly higher in the period of the maximal vasodilation. We also observed a weak synchronization between myogenic BFO of the two skin sites. Our results suggested that synchronization of BFO may be associated with the changes in skin blood flow at the non-heated site.