Synthesis of photoaffinity probes of tautomycin
Synthesis of photoaffinity probes of tautomycin
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DOI：
10.1016/j.tet.2003.12.053
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发表时间：
2004-02-16
期刊：
影响因子：
2.1
通讯作者：
Isobe, M
中科院分区：
文献类型：
--
作者：
Kurono, M;Shimomura, A;Isobe, M
两种类型的光亲和性：制备了在互变霉素2-位上具有二苯甲酮或二氮杂环丙烷的探针，以证明与PP 1结合位点的细节。这些光亲和探针的结构-活性关系的基础上设计的，因此，二酸部分是必不可少的。通过互变霉素二酸的2-肟实现了在互变霉素2-位上选择性引入光标记单元。(C)2004爱思唯尔有限公司保留所有权利。
Two types of photoaffinity: probe, which possesses a benzophenone or a diazirine photophore on the 2-position of tautomycin, were prepared in order to prove the details of binding site to PP1. These photoaffinity probes were designed on the basis of the structure-activity relationship; thus, the diacid moiety is indispensable. The selective introduction of photolabeling units on the 2-position of tautomycin was achieved through the 2-oxime of tautomycin diacid. (C) 2004 Elsevier Ltd. All rights reserved.