A heparin-binding protein from neuroblastoma cells: immunological comparison to beta-amyloid precursor protein.
A heparin-binding protein from neuroblastoma cells: immunological comparison to beta-amyloid precursor protein.
复制标题
来自神经母细胞瘤细胞的肝素结合蛋白：与 β-淀粉样前体蛋白的免疫学比较。
DOI：
10.1016/0300-9629(91)90395-s
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Duffy,LK
中科院分区：
文献类型：
--
作者：
Zhao,XH;Schoenheit,C;Duffy,LK
1. beta-Amyloid precursor protein cross-reactive polypeptides were detected in the membrane extracts of a mouse neuroblastoma cell line, NB41A3. Four immunoreactive polypeptide bands were observed on western blots of a cell membrane extract. Their molecular weights as estimated by polyacrylamide gel electrophoresis ranged from 89.1 to 41 kDa. 2. After heparin affinity chromatography, two of these polypeptides strongly cross-reacted with an antibody that recognizes Alzheimer beta-amyloid precursor protein. 3. From the heparin binding fraction, these protein were further separated by reverse-phase high-performance liquid chromatography. A cross-reactive protein was isolated.
