NuRD and pluripotency: a complex balancing act.

NuRD and pluripotency: a complex balancing act.
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DOI:
10.1016/j.stem.2012.04.011
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发表时间:
2012-05-04
期刊:
影响因子:
23.9
通讯作者:
Wade, Paul A.
Wade, Paul A.
中科院分区:
医学1区
文献类型:
--
作者:
Hu, Guang;Wade, Paul A.

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胚胎干细胞(ESC)由两个基本特征定义-多能性和自我更新-其平衡需要信号转导途径,转录因子网络和表观遗传调节因子的协同作用。最近的研究结果表明,NuRD染色质重塑复合物参与了ESC调控途径的复杂编排。
Embryonic stem cells (ESCs) are defined by two essential features - pluripotency and self-renewal - whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.
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