POPULATION CHARACTERISTICS OF CYCLODEXTRIN COMPLEX STABILITIES IN AQUEOUS-SOLUTION
POPULATION CHARACTERISTICS OF CYCLODEXTRIN COMPLEX STABILITIES IN AQUEOUS-SOLUTION
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DOI：
10.1002/jps.2600840712
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发表时间：
1995-07-01
影响因子：
3.8
通讯作者：
CONNORS, KA
中科院分区：
文献类型：
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作者：
CONNORS, KA
从已发表的来源收集α-环糊精、β-环糊精和γ-环糊精与许多底物（客体）的1：1复合物的结合常数（K-11），并进行统计分析。所有系统均指25 +/- 5 ℃和水溶液。log K-11的频率分布可用具有以下参数的正态分布来描述（n =复合物的数量，mu =总体平均值，σ =总体标准偏差）：α-环糊精，n = 663，mu = 2.11，σ = 0.90; β-环糊精，n = 721，mu = 2.69，σ = 0.89; γ-环糊精，n = 166，μ = 2.55，σ = 0.93。环糊精复合物与一个共同的底物对的稳定性并不精确相关，但它们似乎并不是完全独立的量。α-环糊精复合物的稳定性与最近对α-环糊精复合物稳定性的溶剂效应的解释一致。
Binding constants (K-11) of 1:1 complexes of alpha-cyclodextrin, beta-cyclodextrin, and gamma-cyclodextrin with many substrates (guests) were collected from published sources and subjected to statistical analysis. All systems refer to 25 +/- 5 degrees C and aqueous solution. The frequency distributions of log K-11 are satisfactorily described by normal distributions with the following parameters (n = number of complexes, mu = population mean, sigma = population standard deviation): alpha-cyclodextrin, n = 663, mu = 2.11, sigma = 0.90; beta-cyclodextrin, n = 721, mu = 2.69, sigma = 0.89; gamma-cyclodextrin, n = 166, mu = 2.55, sigma = 0.93. Stabilities of pairs of cyclodextrin complexes with a common substrate are not precisely correlated, but they do not appear to be wholly independent quantities. The stabilities of alpha-cyclodextrin complexes are consistent with a recent interpretation of solvent effects on alpha-cyclodextrin complex stabilities.