Behaviour Preservation of a Biological Regulatory Network when Embedded into a Larger Network
Behaviour Preservation of a Biological Regulatory Network when Embedded into a Larger Network
复制标题
嵌入更大网络时生物调节网络的行为保持
DOI：
10.3233/fi-2009-0052
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
F. Tahi
中科院分区：
文献类型：
--
作者：
G. Bernot;F. Tahi
这项工作的主要贡献是一个数学定理，该定理建立了当遗传调控网络嵌入到更大的网络中时保持其行为的充分必要条件。我们采用 Rene Thomas 的建模方法，它提供了生物调节网络的离散表示。该框架完全使用标记图进行形式化，其语义是根据带有转换的状态图定义的。我们的定理提供了自动验证子网是否具有自主行为的可能性。它将允许生物学家更好地识别应该一起研究的相关基因组。
The main contribution of this work is a mathematical theorem which establishes a necessary and sufficient condition to preserve the behaviour of a genetic regulatory network when it is embedded into a larger network. We adopt the modelling approach of Rene Thomas, which provides a discrete representation of biological regulatory networks. This framework is entirely formalized using labelled graphs with semantics defined in terms of state graphs with transitions. Our theorem offers the possibility to automatically verify whether a subnetwork has autonomous behaviour. It will allow biologists to better identify relevant sets of genes which should be studied together.