MNPs@anionic MOFs/ERGO with the size selectivity for the electrochemical determination of H2O2 released from living cells
MNPs@anionic MOFs/ERGO with the size selectivity for the electrochemical determination of H2O2 released from living cells
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MNPs@阴离子 MOFs/ERGO 具有尺寸选择性，用于电化学测定活细胞释放的 H2O2
DOI：
10.1016/j.bios.2018.05.045
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发表时间：
2018-09-30
影响因子：
12.6
通讯作者：
Ling, Xiaomei
中科院分区：
文献类型：
--
作者：
Li, Cong;Wu, Ruijun;Ling, Xiaomei
本论文采用阳离子交换和电化学还原的方法，构建了阴离子金属有机骨架/电化学还原氧化石墨烯(MNPs@Y-1，4-NDC-MOF/ERGO，M=Ag，Cu)三元复合超细金属纳米颗粒，用于H_2O_2的电化学测定。AgNPs@Y-1，4-NDC-MOF/ERGO和CuNPs@Y-1，4-NDC-MOF/ERGO对H_2O_2均表现出良好的电催化活性，但前者优于后者。这种电催化活性的差异可以用表征测量来解释，结果表明MNPs@Y-1，4-NDC-MOF/ERGO(M=Ag，Cu)电催化剂具有相同的尺寸和电化学比表面积，但电子转移速率常数不同。AgNPs@Y-1，4-NDC-MOF/ERGO传感器的线性检测范围为4~11,000微米，检测下限为0.18微米。此外，该传感器具有良好的抗干扰性，可用于检测活细胞释放的过氧化氢。该传感器充分利用了MNPs的催化性能、Y-1，4-NDC-MOF的尺寸选择性和ERGO的快速电子传输效应。因此，MNPs@Y-1，4-NDC-MOF/ERGO/GCE(M=Ag，Cu)可以通过监测底物和酶存在下产生的过氧化氢来检测酶的活性，具有分子筛分和催化活性的复合材料有望在催化、生物医学和生物传感领域得到广泛的应用。
Herein, the ternary composites, ultrasmall metal nanoparticles encapsulated in the anionic metal-organic frameworks/electrochemically reduced graphene oxide (MNPs@Y-1, 4-NDC-MOF/ERGO, M = Ag, Cu) are constructed by a cationic exchange strategy and an electrochemical reduction process for the electrochemical determination of H2O2. Both AgNPs@Y-1, 4-NDC-MOF/ERGO and CuNPs@Y-1, 4-NDC-MOF/ERGO display excellent electrocatalytic activity toward H2O2, but the former is superior to the latter. Such a difference in electrocatalytic activity can be explained by the characterization measurements, and the results manifest MNPs@Y-1, 4-NDC-MOF/ERGO (M = Ag, Cu) electrocatalysts have subequal MNPs sizes and electrochemical surface areas, but different electron transfer rate constants. The AgNPs@Y-1, 4-NDC-MOF/ERGO sensor shows a linear detection range from 4 to 11,000 mu M with the detection limit of 0.18 mu M. Moreover, MNPs@Y-1, 4-NDC-MOF/ERGO (M = Ag, Cu) exhibit excellent anti-interference performance and can be used for the detection of H2O2 released from living cells. The proposed sensor takes full advantage of the catalytic property of MNPs, the size selectivity of Y-1, 4-NDC-MOF, and the fast electron transport effect of ERGO. Thus, the MNPs@Y-1, 4-NDC-MOF/ERGO/GCE (M = Ag, Cu) can be utilized to detect oxidase activities by monitoring H2O2 produced in the presence of substrate and oxidase, and it is expected that composites with the molecular sieving effect and catalytic activity can be widely applied for catalysis, biomedicine, and biosensing fields.