Partial molecular characterization of two simian immunodeficiency viruses (SIV) from African colobids:: SIVwrc from western red colobus (Piliocolobus badius) and SIVolc from olive colobus (Procolobus verus)
Partial molecular characterization of two simian immunodeficiency viruses (SIV) from African colobids:: SIVwrc from western red colobus (Piliocolobus badius) and SIVolc from olive colobus (Procolobus verus)
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DOI：
10.1128/jvi.77.1.744-748.2003
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发表时间：
2003-01-01
影响因子：
5.4
通讯作者：
Peeters, M
中科院分区：
文献类型：
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作者：
Courgnaud, V;Formenty, P;Peeters, M
为了研究灵长类慢病毒进化的Colobinae亚科，其中只有一个猿猴免疫缺陷病毒（SIV）已被描述到目前为止，我们筛选了其他物种从三个不同属的非洲疣猴SIV感染。血液从13西非colobids，和HIV交叉反应性抗体中观察到5的10 Piliocolobus badius，1的2 Procolobus verus，和0的1 Colobus polykomos标本。对部分pol序列的系统发育分析显示，新的SIV彼此之间的关系比与其他SIV的关系更密切，尤其是与之前描述的来自Colobus guereza的SIVcol不聚簇。这项研究提供的证据表明，这三个属的非洲疣猴自然感染SIV，也表明，有没有病毒和宿主之间的共同进化的Colobinae亚科的水平。
In order to study primate lentivirus evolution in the Colobinae subfamily, in which only one simian immunodeficiency virus (SIV) has been described to date, we screened additional species from the three different genera of African colobus monkeys for SIV infection. Blood was obtained from 13 West African colobids, and HIV cross-reactive antibodies were observed in 5 of 10 Piliocolobus badius, 1 of 2 Procolobus verus, and 0 of 1 Colobus polykomos specimens. Phylogenetic analyses of partial pol sequences revealed that the new SIVs were more closely related to each other than to the other SIVs and especially did not cluster with the previously described SIVcol from Colobus guereza. This study presents evidence that the three genera of African colobus monkeys are naturally infected with an SIV and indicates also that there was no coevolution between virus and hosts at the level of the Colobinae subfamily.