Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese
Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese
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DOI：
10.1253/circj.69.1466
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发表时间：
2005-12-01
影响因子：
3.3
通讯作者：
Sunagawa, K
中科院分区：
文献类型：
--
作者：
Mashiba, J;Koike, G;Sunagawa, K
背景种族和吸烟是冠状动脉血管痉挛发病的众所周知的危险因素。吸烟引起的氧化应激在冠状动脉血管痉挛中起重要作用，但不足以解释冠状动脉血管痉挛的发病机制，说明遗传因素有很强的作用。方法与结果经乙酰胆碱激发试验确诊的162例血管痉挛(VSA)患者、61例微血管心绞痛(MVA)患者和61例无反应者(NRS)。对细胞色素b-245、α-多肽基因C242T和A640G、对氧磷酶1基因(PON1)A632G、磷脂酶A2族基因(PLA2G7)G994T 4个氧化应激相关基因进行了基因分型。PON1 632-G等位基因频率在显性方式的VSA和隐性方式的MVA中均显著高于非显性方式。这种联系只在MVA中受到性别的强烈影响。其他基因多态与冠脉血管痉挛无明显关联。结论PON1 A632G基因多态性与MVA和VSA有显著关联，但对VSA和VSA的影响不同。
Background Ethnicity and smoking are well-known risk factors for the pathogenesis of coronary vasospasm. Oxidative stress induced by smoking plays a crucial role in coronary vasospasm, but is not enough to account for the pathogenesis of coronary vasospasm, indicating that genetic factors are strongly involved.Methods and Results The study group comprised 162 vasospastic angina patients (VSAs), 61 microvascular angina patients (MVAs) and 61 non-responders (NRs) diagnosed by acetylcholine provocation test. Four polymorphisms of the oxidative stress related genes, cytochrome b-245, alpha polypeptide gene (CYBA) C242T and A640G, paraoxonase 1 gene (PON1) A632G, phospholipase A2 group VII gene (PLA2G7) G994T were genotyped. Allele frequency of PON1 632-G was significantly higher in both the VSA with dominant fashion and the MVA with recessive fashion compared with NR. This association was strongly influenced by gender in the MVA only. There were no significant associations between the other polymorphisms and coronary vasospasm. In addition, the allele frequency of PON1 632-G in the Japanese was higher than in Caucasians.Conclusions There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese.