Long-term renal function after treatment for malignant germ-cell tumours
Long-term renal function after treatment for malignant germ-cell tumours
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DOI：
10.1093/annonc/mdf048
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发表时间：
2002-02-01
影响因子：
50.5
通讯作者：
Olsen, DR
中科院分区：
文献类型：
--
作者：
Fosså, SD;Aass, N;Olsen, DR
目的：前瞻性评价恶性生殖细胞肿瘤（mgct）患者在单独腹膜后淋巴结清扫（RPLND）、单独放疗（RAD）或不同方案的顺铂为基础的化疗（伴或不伴手术/放疗（CHEM））后10年的肾功能。患者与方法：85例患者分为3组：RPLND 14例；RAD, 18;CHEM, 53，后一组根据累积顺铂剂量或额外使用放疗进行细分。在治疗前和14年随访期间进行4次肾功能评估（134）碘hipuran清除率或（99）m DTPA肾小球滤过率。的值
Objective: To evaluate prospectively renal function in patients with malignant germ-cell tumours (MGCTs) >10 years after retroperitoneal lymph node dissection alone (RPLND), radiotherapy alone (RAD) or different schedules of cisplatin-based chemotherapy with or without surgery/radiotherapy (CHEM).Patients and methods: In 85 patients, three groups were identified: RPLND, 14; RAD, 18; CHEM, 53, with subdivision of the latter group according to the cumulative cisplatin dose or the additional use of radiotherapy. Renal function was determined by (134)Iodine Hippuran clearance or (99)m DTPA glomerular filtration rate, and was assessed before treatment and four times during 14 years of follow-up. A value of