High neutrophil-to-lymphocyte ratio predicts acute allograft rejection in kidney transplantation: a retrospective study
High neutrophil-to-lymphocyte ratio predicts acute allograft rejection in kidney transplantation: a retrospective study
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DOI：
10.3906/sag-1811-41
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发表时间：
2019-01-01
影响因子：
2.3
通讯作者：
Arinsoy, Turgay
中科院分区：
文献类型：
--
作者：
Ergin, Giray;Deger, S. Muge;Arinsoy, Turgay
背景/目的：我们的研究集中在识别容易获得和敏感的标记物，用于早期预测急性肾移植排斥反应（AR）。我们的目的是调查之间的关联嗜中性粒细胞-淋巴细胞比率（NLR）和AR在肾transplantationpatients.Materials和方法：51例肾移植患者的病历[12名女性/39名男性，中位年龄为32（IQR：24-44）岁]进行了回顾性评价。我们认为临界值>2.5为高NLR.Results：共22例活检证实的AR患者和29例对照进行了评价。AR组NLR明显高于对照组（P < 0.001）。在单因素分析中，NLR水平超过2.5 [95%CI：54.88（9.96-302.3），P < 0.001]与AR显著相关。在多变量模型中，NIA水平是与AR相关的唯一显著因素，在模型1中（按年龄和性别调整）[95% CI：114（11.1-1175），P < 0.001]，模型2中（经类固醇剂量、尿酸和NLR调整）195% CI：4.60（1.59-29.3），P = 0.004]。结论：我们的数据表明，较高的NLR值（>2.5）与肾移植患者的AR相关，从而得出结论，NLR可能是检测该患者人群中AR的一种容易获得且有用的标记物选择。
Background/aim: Our research focused on the identification of easily available and sensitive markers for early prediction of acute kidney allograft rejection (AR). We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR in kidney transplant patients.Materials and methods: The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24-44) years] were evaluated retrospectively. We considered a cut-off value of >2.5 as high NLR.Results: A total of 22 biopsy-proven AR patients and 29 controls were evaluated. The AR group had a higher NLR compared to the controls (P < 0.001). NLR levels over 2.5 [95% CI: 54.88 (9.96-302.3), P < 0.001] were significantly associated with AR in univariate analysis. The NIA levels were the only significant factor associated with AR in multivariate models, in model 1 (adjusted by age and sex) [95% CI: 114 (11.1-1175), P < 0.001], and in model 2 (adjusted by steroid dosage, uric acid, and NLR) 195% CI: 4.60 (1.59-29.3), P = 0.004].Conclusion: Our data showed that higher NLR values (>2.5) are associated with AR in kidney transplant patients, leading to the conclusion that NLR might be an easily available and useful marker option for detection of AR in this patient population.