XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis
XPNPEP2 is overexpressed in cervical cancer and promotes cervical cancer metastasis
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XPNPEP2在宫颈癌中过表达并促进宫颈癌转移
DOI：
10.1177/1010428317717122
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Xi Ling
中科院分区：
文献类型：
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作者：
Cheng Teng;Wei Rui;Jiang Guiying;Zhou Ying;Lv Mengqin;Dai Yun;Yuan Yuan;Luo Danfeng;Ma Ding;Li Fei;Xi Ling
XPNPEP2是一种脯氨酸水解酶，它水解了几种生物活性肽并导致底物活性的损失。但是，其在癌症中的功能仍然未知。我们的研究表明，与正常的宫颈组织和上皮内肿瘤组织相比，宫颈癌组织中XPNPEP2的表达显着上调。统计分析表明，XPNPEP2表达与国际妇科和妇产科联盟和淋巴结转移有关。 SIHA和HeLa细胞中XPNPEP2的过表达促进了细胞侵袭和迁移，而不会影响细胞增殖和凋亡。从机械上讲，我们发现XPNPEP2通过诱导上皮 - 间质转变来促进宫颈癌细胞侵袭和迁移。此外，我们证明XPNPEP2对体内异种移植肿瘤的转移具有显着影响。总体而言，我们的发现确定了XPNPEP2在宫颈癌转移中的新功能，并表明XPNPEP2可能是治疗宫颈癌的新型治疗靶标。
XPNPEP2 is a proline hydrolytic enzyme that hydrolyzes several biologically active peptides and causes a loss of substrate activity. However, its function in cancer is still unknown. Our study showed that XPNPEP2 expression was significantly upregulated in cervical cancer tissues compared with normal cervical tissues and cervical intraepithelial neoplasm tissues. Statistical analysis showed that XPNPEP2 expression was associated with the International Federation of Gynecology and Obstetrics stage and lymph node metastasis. Overexpression of XPNPEP2 in SiHa and HeLa cells promoted cell invasion and migration without affecting cell proliferation and apoptosis. Mechanistically, we found that XPNPEP2 facilitated cervical cancer cell invasion and migration by inducing epithelial–mesenchymal transition. Furthermore, we demonstrated that XPNPEP2 had significant effects on the metastasis of xenografted tumors in vivo. Collectively, our findings identify the novel function of XPNPEP2 in the metastasis of cervical cancer and suggest that XPNPEP2 could be a novel potential therapeutic target for the treatment of cervical cancer.