Single-Nucleotide Polymorphism in the fadD28 Gene as a Genetic Marker for East Asia Lineage Mycobacterium tuberculosis
Single-Nucleotide Polymorphism in the fadD28 Gene as a Genetic Marker for East Asia Lineage Mycobacterium tuberculosis
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DOI：
10.1128/jcm.00970-10
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发表时间：
2010-11-01
影响因子：
9.4
通讯作者：
Jou, Ruwen
中科院分区：
文献类型：
--
作者：
Chuang, Pei-Chun;Chen, Huang-Yau;Jou, Ruwen
具有RD105区缺失的结核分枝杆菌分离株，主要是北京家庭的分枝杆菌，在系统发育上归入东亚谱系。我们确定了fadD28基因507密码子ATC至ATT的单核苷酸多态是一种可靠的标记，并建立了一种快速检测东亚血统结核分枝杆菌的方法。
Mycobacterium tuberculosis isolates with a region of difference 105 (RD105) deletion, mainly Beijing family spoligotypes, were phylogenetically grouped into the East Asia lineage. We identified a single nucleotide polymorphism in codon 507, ATC to ATT, of the fadD28 gene as a robust marker and developed a rapid assay for East Asia lineage M. tuberculosis.