Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems.
Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems.
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DOI：
10.4049/jimmunol.1601775
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发表时间：
2017-07-01
期刊：
影响因子：
--
通讯作者：
Boyaka PN
中科院分区：
文献类型：
--
作者：
Boyaka PN
粘液伊加或分泌型伊加（SIgA）在结构上装备成抵抗粘膜表面的恶劣环境中的化学降解和宿主或微生物来源的酶。SIgA的产生受到精细调节，并且不同的T非依赖性和T依赖性机制协调免疫球蛋白重链α类转换和针对真菌和病原微生物的SIgA应答。大多数感染性病原体通过粘膜表面进入宿主。为了在这些入境口岸提供第一线保护，除了通过注射疫苗实现的全身免疫外，正在开发疫苗以诱导病原体特异性SIgA。粘膜或表皮递送疫苗有助于靶向伊加应答的诱导位点。此类疫苗的功效依赖于能够支持SIgA的发展的疫苗佐剂的鉴定/工程化以及改善疫苗递送至靶向解剖部位和免疫细胞的全身免疫和递送系统。
Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist chemical degradation in the harsh environment of mucosal surfaces and the enzymes of host or microbial origin. Production of SIgA is finely regulated and distinct T-independent and T-dependent mechanisms orchestrate immunoglobulin heavy chain α class switching and SIgA responses against commensal and pathogenic microbes. Most infectious pathogens enter the host via mucosal surfaces. To provide a first line of protection at these entry ports, vaccines are being developed to induce pathogen-specific SIgA in addition to systemic immunity achieved by injected vaccines. Mucosal or epicutaneous delivery of vaccines helps target the inductive sites for IgA responses. The efficacy of such vaccines relies on the identification/engineering of vaccine adjuvants capable of supporting the development of SIgA alongside systemic immunity and delivery systems that improve vaccine delivery to the targeted anatomic sites and immune cells.
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影响因子：
32.4
作者：
Bunker JJ;Flynn TM;Koval JC;Shaw DG;Meisel M;McDonald BD;Ishizuka IE;Dent AL;Wilson PC;Jabri B;Antonopoulos DA;Bendelac A
通讯作者：
Bendelac A
影响因子：
4.4
作者：
Boullier, Severine;Tanguy, Myriam;Phalipon, Armelle
通讯作者：
Phalipon, Armelle
DOI：
10.4049/jimmunol.0803740
发表时间：
2009-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cuburu N;Kweon MN;Hervouet C;Cha HR;Pang YY;Holmgren J;Stadler K;Schiller JT;Anjuère F;Czerkinsky C
通讯作者：
Czerkinsky C
影响因子：
10.8
作者：
Davitt, Christopher J. H.;McNeela, Edel A.;Lavelle, Ed C.
通讯作者：
Lavelle, Ed C.
影响因子：
32.4
作者：
Chu, Van Trung;Beller, Alexander;Berek, Claudia
通讯作者：
Berek, Claudia