Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment
Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment
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DOI：
10.1016/j.clinph.2020.02.015
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发表时间：
2020-05-01
影响因子：
4.7
通讯作者：
Rossini, Paolo Maria
中科院分区：
文献类型：
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作者：
Brunetti, Valerio;D'Atri, Aurora;Rossini, Paolo Maria
目的：最近的研究结果表明，在相当大比例的阿尔茨海默病（AD）患者中，睡眠期间普遍存在亚临床癫痫样活动。我们研究的目的是：(A)比较被诊断为“可能的”阿尔茨海默病和由阿尔茨海默病引起的轻度认知障碍（MCI）的样本和健康受试者在睡眠期间亚临床癫痫样活动的频率；(B)在控制良好的多导睡眠图设置下，评估癫痫样脑电图活动作为不同睡眠阶段的功能。方法：我们前瞻性地招募了50名“可能的”AD患者（73 +/- 7.0岁）和50名无癫痫发作史的AD所致MCI患者（72 +/- 6.7岁），与50名对照组（69 +/- 6.7岁）进行比较。患者接受了通宵视频psg。结果：在6.38%的“可能”AD患者、11.63%的AD患者和4.54%的对照组中检测到亚临床癫痫样活动（p = 0.43）。三组之间的癫痫样活动频率的比较，无论是在总睡眠时间还是在任何睡眠时间，都没有达到统计学上的显著差异。结论：我们的研究表明，在控制睡眠阶段和精神活性药物的影响时，AD患者和AD患者引起的MCI在睡眠期间没有比健康受试者表现出更高的癫痫样放电频率。意义：睡眠期间的亚临床癫痫样活动不能区分“可能的”AD与由AD和健康对照引起的MCI。(C) 2020国际临床神经生理学联合会。Elsevier B.V.版权所有。
Objective: Recent findings suggested that subclinical epileptiform activity is prevalent during sleep in a significant proportion of Alzheimer's Disease (AD) patients. The aims of our study were: (A) comparing the frequency of subclinical epileptiform activity during the sleep in a sample diagnosed with 'probable' AD and Mild Cognitive Impairment (MCI) due to AD, and in healthy subjects; (B) evaluating epileptiform EEG activity as a function of different sleep stages within a well-controlled polysomnographic setting.Methods: We prospectively enrolled 50 'probable' AD patients (73 +/- 7.0 years) and 50 subjects with MCI due to AD (72 +/- 6.7 years) without history of seizures, comparing them with 50 controls (69 +/- 6.7 years). Patients underwent to a full-night video-PSG.Results: Subclinical epileptiform activity was detected in 6.38% of 'probable' AD patients, 11.63% of MCI due to AD subjects and 4.54% of controls (p = 0.43). The comparisons between the three groups for the frequency of epileptiform activity did not reach statistically significant differences neither for total sleep nor for any sleep period considered.Conclusions: Our study shows that, when controlling for sleep stages and the influence of psychoactive drugs, AD patients and MCI due to AD subjects do not exhibit a higher frequency of epileptiform discharges during sleep compared to healthy subjects.Significance: Subclinical epileptiform activity during sleep does not discriminate 'probable' AD from MCI due to AD and healthy controls. (C) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.