Role of neutrophil/lymphocyte ratio in prediction of disease progression in patients with stage-4 chronic kidney disease
Role of neutrophil/lymphocyte ratio in prediction of disease progression in patients with stage-4 chronic kidney disease
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DOI：
10.5301/jn.5000152
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发表时间：
2013-03-01
影响因子：
3.4
通讯作者：
Utas, Cengiz
中科院分区：
文献类型：
--
作者：
Kocyigit, Ismail;Eroglu, Eray;Utas, Cengiz
背景：慢性肾脏病（CKD）在没有任何干预的情况下往往进展为终末期肾病。中性粒细胞/淋巴细胞（N/L）比值可能指示潜在的炎症状态。我们的目的是调查的N/L比值的作用，预测进展到透析的患者4期CKD.Methods：我们纳入了105例4期CKD患者的研究。所有患者均从首次入院接受透析开始进行随访。在随访期间测量NIL比率。结果：N/L比值≥ 3的患者病情进展率高于N/L比值≥ 3的患者（P <0.05），而N/L比值≥ 3的患者病情进展率高于N/L比值≥ 3的患者（P <0.05），且N/L比值≥ 3的患者病情进展率高于N/L比值≥ 3的患者（P <0.05
Background: Chronic kidney disease (CKD) tends to progress to end-stage renal disease without any intervention. Neutrophil/lymphocyte (N/L) ratio may be indicative of an underlying inflammatory state. We aimed to investigate the role of N/L ratio for prediction of progression to dialysis in patients with stage 4 CKD.Methods: We included 105 patients with stage 4 CKD in the study. All patients were followed up from the first admission to dialysis. NIL ratio was measured during follow-up. Patients were divided into two groups as baseline N/L (N/Lb) ratio = 3 and rapid progression was defined as > 5 mL/minute/year loss of creatinine clearance and slow progression as < 5 mL/minute/year.Results: Patients with N/L ratio >= 3 demonstrated high progression rate compared to patients who had N/L ratio