The hedgehog signaling pathway in cancer
The hedgehog signaling pathway in cancer
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DOI：
10.1158/1078-0432.ccr-06-1736
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发表时间：
2006-10-15
影响因子：
11.5
通讯作者：
de Sauvage, Frederic J.
中科院分区：
文献类型：
--
作者：
Evangelista, Marie;Tian, Hua;de Sauvage, Frederic J.
Hedgehog(H H)途径是一个信号级联信号通路，指导大多数动物的模式形成，对正常发育至关重要。在分子水平上，HH配体驱动某些细胞类型的细胞增殖，同时导致其他细胞类型的分化。HH信号在胚胎发育过程中最为活跃，成人组织中HH信号通路的异常重新激活可能导致癌症的发生。全面了解HH信号在发育过程中的作用，无疑将有助于阐明HH在癌症进展中的作用机制，并确定潜在的治疗干预靶点。
The Hedgehog (H h) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway in adult tissue can lead to the development of cancer. A comprehensive understanding of Hh signaling during development will undoubtedly shed light into the mechanism of Hh in cancer progression and identify potential targets for therapeutic intervention.