Pre-surgical cortical activation to food pictures is associated with weight loss following bariatric surgery
Pre-surgical cortical activation to food pictures is associated with weight loss following bariatric surgery
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DOI：
10.1016/j.soard.2014.06.005
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发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Savage, Cary R.
中科院分区：
文献类型：
--
作者：
Ness, Abigail;Bruce, Jared;Savage, Cary R.
背景：最近的研究表明，介入前功能磁共振成像(FMRI)数据可以预测参与行为减肥计划的患者的减肥结果。目前还没有研究检验手术前大脑激活是否可以预测减肥手术后的结果。方法：本研究的目的是确定手术前功能磁共振食物激励范例中的大脑激活是否与腹腔镜可调节胃束带(LAGB)术后3个月和6个月体重减轻有关。在LAGB手术前的fMRI扫描过程中，19名参与者观看了来自完善的食物动机范式的食物和非食物图片。在手术前、术后3个月和6个月评估体重；所有参与者的数据在每个时间点都可用。使用BrainVoyager QX统计软件包对fMRI数据进行分析。对手术前(食物-非食物)脑激活和体重的全脑体素相关性进行了多次比较校正，以分析术前脑激活和随后体重减轻之间的关系。实验环境是一个医科大学脑成像中心和两个外科减肥中心。结果：与认知控制相关的额叶区域(内侧、额中、额上回)和后扣带回的活动增加与LAGB后的体重下降相关。结论：我们发现，先前建立的与认知和行为自我调节相关的区域的神经活动预测减肥手术后的体重下降。这些初步发现强调了神经回路在成功和维持体重减轻中的作用，并提示未来可能使用功能磁共振来筛查LAGB手术候选人。(C)2014年美国新陈代谢和减肥外科学会。版权所有。
Background: Recent research suggests that preintervention functional magnetic resonance imaging (fMRI) data may predict weight loss outcomes among patients who participate in a behavioral weight loss plan. No study has examined whether presurgical brain activation can predict outcomes following bariatric surgery.Method: The aim of the present study was to determine if brain activations during a presurgical fMRI food-motivation paradigm are associated with weight loss 3 and 6 months following laparoscopic adjustable gastric banding (LAGB). Nineteen participants viewed food and nonfood pictures from a well-established food motivation paradigm during an fMRI scanning session before LAGB surgery. Weight was assessed presurgery and 3 and 6 months postsurgery; data for all participants was available at each time point. fMRI data were analyzed using the BrainVoyager QX statistical package. Whole brain voxelwise correlations of presurgery (food-nonfood) brain activation and weight, corrected for multiple comparisons, were performed to analyze the relationship between presurgical brain activation and subsequent weight loss. The settings were a medical university brain imaging center and 2 surgical weight loss centers in a major metropolitan area.Results: Increased activity in frontal regions associated with cognitive control (medial, middle, superior frontal gyms) and posterior cingulate cortex was associated with weight loss following LAGB.Conclusion: We found that neural activity in previously established regions associated-with cognitive and behavioral self-regulation predicts weight loss following bariatric surgery. These preliminary findings highlight the role of neural circuitry in the success and maintenance of weight loss and suggest a possible future use of fMRI in screening LAGB surgery candidates. (C) 2014 American Society for Metabolic and Bariatric Surgery. All rights reserved.