Synaptic Properties of Thalamic Input to Layers 2/3 and 4 of Primary Somatosensory and Auditory Cortices
Synaptic Properties of Thalamic Input to Layers 2/3 and 4 of Primary Somatosensory and Auditory Cortices
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DOI：
10.1152/jn.00747.2010
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发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
Sherman, S. Murray
中科院分区：
文献类型：
--
作者：
Viaene, Angela N.;Petrof, Iraklis;Sherman, S. Murray
Viaene An，Petrof I，Sherman SM。丘脑传入初级躯体感觉和听觉皮质第2/3层和第4层的突触特性。神经生理学杂志105：279-292,2011。2010年11月3日首次出版；DOI：10.1152/jn.00747.2010。我们使用出生后10-18天小鼠的丘脑皮质切片，研究了丘脑传入初级躯体感觉(S1)和听觉(A1)皮质第2/3层和第4层细胞的突触轮廓。刺激内侧膝状体腹后内侧核(VPM)或内侧膝状体腹侧分支(MGBv)可引起两种不同类型的反应。所有第4层细胞和少数第2/3层细胞对丘脑刺激的反应为1类，包括成对脉冲抑制、全有或无反应，以及缺乏代谢性成分。另一方面，第2/3层的大多数神经元对丘脑刺激表现出明显不同的2类反应：成对脉冲促进、分级反应和代谢性成分。1类和2类反应特征以前已经在丘脑的输入中看到，并分别被描述为驱动因素和调节因素。驾驶员输入是决定突触后神经元感受野特性的主要信息承载途径，而调制器输入则影响突触后神经元的反应特性，但不是主要的信息承载输入。因为这些丘脑皮质投射与丘脑中的驱动因子和调节器具有类似的特性，我们认为驱动因子/调制因子的区别也可能适用于丘脑皮质投影。此外，我们的数据表明，丘脑很可能不仅仅是简单的信息传递，还可能直接调节皮质。
Viaene AN, Petrof I, Sherman SM. Synaptic properties of thalamic input to layers 2/3 and 4 of primary somatosensory and auditory cortices. J Neurophysiol 105: 279-292, 2011. First published November 3, 2010; doi:10.1152/jn.00747.2010. We studied the synaptic profile of thalamic inputs to cells in layers 2/3 and 4 of primary somatosensory (S1) and auditory (A1) cortices using thalamocortical slices from mice age postnatal days 10-18. Stimulation of the ventral posterior medial nucleus (VPM) or ventral division of the medial geniculate body (MGBv) resulted in two distinct classes of responses. The response of all layer 4 cells and a minority of layers 2/3 cells to thalamic stimulation was Class 1, including paired-pulse depression, all-or-none responses, and the absence of a metabotropic component. On the other hand, the majority of neurons in layers 2/3 showed a markedly different, Class 2 response to thalamic stimulation: paired-pulse facilitation, graded responses, and a metabotropic component. The Class 1 and Class 2 response characteristics have been previously seen in inputs to thalamus and have been described as drivers and modulators, respectively. Driver input constitutes a main information bearing pathway and determines the receptive field properties of the postsynaptic neuron, whereas modulator input influences the response properties of the postsynaptic neuron but is not a primary information bearing input. Because these thalamocortical projections have comparable properties to the drivers and modulators in thalamus, we suggest that a driver/modulator distinction may also apply to thalamocortical projections. In addition, our data suggest that thalamus is likely to be more than just a simple relay of information and may be directly modulating cortex.