Alterations in theory of mind in patients with schizophrenia and non-psychotic relatives
Alterations in theory of mind in patients with schizophrenia and non-psychotic relatives
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DOI：
10.1034/j.1600-0447.2003.00092.x
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发表时间：
2003-08-01
影响因子：
6.7
通讯作者：
van Os, J
中科院分区：
文献类型：
--
作者：
Janssen, I;Krabbendam, L;van Os, J
目的：有人提出，心理理论的改变是精神病特定症状的基础。本研究探讨了心理理论的改变是否反映了精神分裂症患者的非精神病亲属中可以检测到的特征。 方法：参与者包括 43 名精神分裂症或分裂情感障碍患者、41 名一级非精神病亲属和 43 名来自普通人群的对照。使用暗示任务和错误信念任务评估心理理论。结果：精神分裂症风险与暗示任务失败之间存在显着相关性（OR 线性趋势 = 2.01，95% CI：1.22-3.31），亲属在患者和对照之间具有中间值。对智商和神经心理学因素的调整会少量减少这种关联。精神分裂症风险与错误信念任务失败之间的关联并不显着。结论：心理理论的变化与精神分裂症责任相关。一般认知能力和神经心理学测量似乎只能调节这种关联的一部分。
Objective: It has been proposed that alterations in theory of mind underlie specific symptoms of psychosis. The present study examined whether alterations in theory of mind reflect a trait that can be detected in non-psychotic relatives of patients with schizophrenia.Method: Participants were 43 patients with schizophrenia or schizoaffective disorder, 41 first-degree non-psychotic relatives and 43 controls from the general population. Theory of mind was assessed using a hinting task and a false-belief task.Results: There was a significant association between schizophrenia risk and failure on the hinting task (OR linear trend = 2.01, 95% CI: 1.22-3.31), with relatives having intermediate values between patients and controls. Adjustment for IQ and neuropsychological factors reduced the association by small amounts. The association between schizophrenia risk and failure on the false-belief tasks was not significant.Conclusion: Changes in theory of mind are associated with schizophrenia liability. General cognitive ability and neuropsycholo- gical measures seem to mediate only part of this association.