Adeno-associated virus-mediated cancer gene therapy: current status.

Adeno-associated virus-mediated cancer gene therapy: current status.
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腺相关病毒介导的癌症基因治疗:现状

DOI:
10.1016/j.canlet.2014.10.045
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发表时间:
2015-01-28
期刊:
影响因子:
9.7
通讯作者:
Yang, Xiaoming
Yang, Xiaoming
中科院分区:
医学1区
文献类型:
--
作者:
Luo, Jingfeng;Luo, Yuxuan;Sun, Jihong;Zhou, Yurong;Zhang, Yajing;Yang, Xiaoming

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基因治疗是现代医学的前沿领域之一。腺相关病毒(AAV)介导的基因治疗正在成为治疗多种疾病和癌症的有前途的方法。 AAV介导的癌症基因疗法由于其相对于其他基因携带载体的优越性而迅速发展,例如缺乏致病性、能够转染分裂和非分裂细胞、宿主免疫反应低以及长期表达。本文回顾并提供了 AAV 介导的癌症基因治疗的最新知识。
Gene therapy is one of the frontiers of modern medicine. Adeno-associated virus (AAV)-mediated gene therapy is becoming a promising approach to treat a variety of diseases and cancers. AAV-mediated cancer gene therapies have rapidly advanced due to their superiority to other gene-carrying vectors, such as the lack of pathogenicity, the ability to transfect both dividing and non-dividing cells, low host immune response, and long-term expression. This article reviews and provides up to date knowledge on AAV-mediated cancer gene therapy.
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