Behavioral effects of amylin injected intracerebroventricularly in the rat
Behavioral effects of amylin injected intracerebroventricularly in the rat
复制标题
DOI：
10.1016/0196-9781(96)00062-9
复制
发表时间：
1996-01-01
期刊：
影响因子：
3
通讯作者：
Drago, F
中科院分区：
文献类型：
--
作者：
Clementi, G;Valerio, C;Drago, F
胰淀素是一种起源于胰腺的肽，据报道，它在大脑中具有高亲和力的结合位点，并影响中枢多巴胺能和血清素能神经传递。注射ICV后，肽诱导了运动活动的剂量依赖性减少，而不影响梳理和嗅探。在5 μ g/大鼠剂量下，它可以拮抗SC注射安非他明（2mg /kg）或多巴胺受体激动剂阿波啡（250mg /kg）引起的运动性亢进和刻板印象。氟哌啶醇（0.5 mg/kg， SC）对运动活动、修饰和嗅探的影响没有显著改变Amylin。此外，注射5-HT2拮抗剂利坦色林（2mg /kg， SC）后，该肽不会改变动物的运动行为。这些结果表明，胰淀素可能通过干扰中枢多巴胺能神经传递来发挥运动作用。
Amylin is a peptide of pancreatic origin that has been reported to possess high-affinity binding sites in the brain and to affect central dopaminergic and serotonergic neurotransmission. Administered ICV the peptide induced a dose-dependent decrease of locomotor activity without affecting grooming and sniffing. At a dose of 5 mu g/rat, it antagonized the hypermotility and stereotypies induced by SC injection of amphetamine (2 mg/kg) or of the dopamine receptor agonist, apomorphine (250 mg/kg). Amylin did not change significantly the effect of haloperidol (0.5 mg/kg, SC) on locomotor activity, grooming, and sniffing. Moreover, the peptide did not modify the locomotor behavior of animals injected with the 5-HT2 antagonist, ritanserin (2 mg/kg, SC). These results suggest that amylin may exert motor effects, probably by interfering with central dopaminergic neurotransmission.