Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome
Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome
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继发于斯特奇-韦伯综合征的青光眼房水的特征性细胞因子谱
DOI：
10.3389/fimmu.2020.00004
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发表时间：
2020-01-28
影响因子：
7.3
通讯作者：
Guo, Wenyi
中科院分区：
文献类型：
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作者：
Peng, Cheng;Wu, Yue;Guo, Wenyi
斯特奇-韦伯综合征（SWS）患者容易出现眼部并发症，其中青光眼是最常见的并发症之一。在当前的研究中，我们利用多重人细胞因子抗体阵列同时测量SWS诱发的青光眼（SG）患者或作为对照的老年性白内障患者的房水中（AH）中40种细胞因子的浓度。与对照组相比,SG组AH中白介素(IL)-12p40、巨噬细胞炎症蛋白(MIP)-1d、肿瘤坏死因子-α(TNF-a)、IL-5、IL-7、白介素-6受体(IL-6R)、B淋巴细胞趋化物(BLC)水平显着升高。 SG 患者样本中 MIP-1b、IL-6、MIP-1a 和单核细胞趋化蛋白 (MCP)-1 的水平显着低于对照组。进一步分析显示早发性SG患者IL-7、MIP-1a、TNF-a与眼压（IOP）呈正相关。此外，IL-12p40 与 SG 患者的年龄呈负相关。这些细胞因子可能有助于 SWS 患者青光眼的免疫发病或进展。
Patients with Sturge-Weber syndrome (SWS) are susceptible to ocular complications, and among them, glaucoma is one of the most frequent forms. In current study, we utilized multiplex human cytokine antibody array to simultaneously measure the concentration of 40 cytokines in aqueous humor (AH) of patients with SWS-induced glaucoma (SG), or from patients with senile cataract as controls. Compared with the control group, levels of interleukin (IL)-12p40, macrophage inflammatory protein (MIP)-1d, tumor necrosis factor-alpha (TNF-a), IL-5, IL-7, interleukin-6 receptor (IL-6R), and B lymphocyte chemoattractant (BLC) in AH were significantly higher in SG group. Samples from SG patients displayed significantly lower levels of MIP-1b, IL-6, MIP-1a, and monocyte chemoattractant protein (MCP)-1 than controls. Further analysis showed that IL-7, MIP-1a, TNF-a were positively correlated with intraocular pressure (IOP) in patients with early-onset SG. Moreover, IL-12p40 was negatively correlated with age in patients with SG. These cytokines may make contributions to the immunopathogenesis or progression of glaucoma in patients with SWS.