How does TGF-β mediate tubulointerstitial fibrosis?
How does TGF-β mediate tubulointerstitial fibrosis?
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DOI：
10.1016/j.semnephrol.2012.04.001
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发表时间：
2012-05
影响因子：
3.3
通讯作者：
Zent R
中科院分区：
文献类型：
--
作者：
Gewin L;Zent R
肾小管间质纤维化介导各种病因的肾损伤导致终末期肾病的发展，被认为是肾存活率的重要预测因素。转化生长因子-β（Transforming growth factor-β，TGF-β）是促进肾小管间质纤维化的最重要的生长因子之一，但其发生机制尚不清楚。这是因为TGF-β具有依赖于靶细胞类型的多效性作用。这篇综述讨论了TGF-β信号在每种相关细胞类型（如肾小管上皮细胞、成纤维细胞）中如何促进肾小管间质纤维化进展，并提出了未来研究可以提高我们对TGF-β介导的肾小管间质纤维化的理解的方法。
Tubulointerstitial fibrosis mediates the development of end-stage renal disease from renal injuries of all etiologies and is considered an important predictor of renal survival. Transforming growth factor-β (TGF-β) is one of the most important growth factors which promotes tubulointerstitial fibrosis, but the mechanisms whereby this occurs are not well-defined. This is because TGF-β has pleiotropic effects that depend upon the target cell type. This review discusses how TGF-β signaling in each of the relevant cell types (e.g. tubular epithelium, fibroblasts) may contribute to tubulointerstitial fibrosis progression and suggests ways in which future research can improve our understanding of TGF-β-mediated tubulointerstitial fibrosis.