Blood Pressure and Arterial Stiffness in Kenyan Adolescents With the Sickle Cell Trait.
Blood Pressure and Arterial Stiffness in Kenyan Adolescents With the Sickle Cell Trait.
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DOI：
10.1093/aje/kwx232
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发表时间：
2018-02-01
影响因子：
5
通讯作者：
Scott JAG
中科院分区：
文献类型：
--
作者：
Etyang AO;Wandabwa CK;Kapesa S;Muthumbi E;Odipo E;Wamukoya M;Ngomi N;Haregu T;Kyobutungi C;Williams TN;Makale J;Macharia A;Cruickshank JK;Smeeth L;Scott JAG
尽管镰状细胞性状（SCT）与卒中、猝死和肾脏疾病相关，但尚未详细评估其与动脉僵硬度/血压（BP）升高之间的潜在相关性。我们对肯尼亚无疟疾环境中长大的青少年进行了24小时动态血压监测和动脉硬度测量。在2015年12月至2016年6月期间，938名随机选择的青少年（年龄11-17岁）从出生起就连续居住在内罗毕，被邀请参加这项研究。进行标准门诊BP测量，随后进行24小时动态BP监测和使用Arteriograph 24（TensioMed Ltd.，匈牙利布达佩斯）装置。使用同时采集的血液样本中的DNA基因分型确定SCT状态。在938名被邀请参加的青少年中，609名（65%）提供了完整的数据进行分析。SCT存在于103例（15%）中。SCT儿童的平均24小时收缩压和舒张压分别为116（标准差（SD），11.5）mm Hg和64（SD，7）mm Hg，非SCT儿童的平均24小时收缩压和舒张压分别为117（SD，11.4）mm Hg和64（SD，6.8）mm Hg。SCT和非SCT儿童的平均脉搏波速度（PWV）分别为7.1（SD，0.8）m/s和7.0（SD，0.8）m/s。我们观察到青少年SCT和非SCT患者之间的PWV或任何门诊或门诊BP衍生指标无差异。这些数据表明，SCT不会独立影响BP或PWV。
The potential association between sickle cell trait (SCT) and increased arterial stiffness/blood pressure (BP) has not been evaluated in detail despite its association with stroke, sudden death, and renal disease. We performed 24-hour ambulatory BP monitoring and arterial stiffness measurements in adolescents raised in a malaria-free environment in Kenya. Between December 2015 and June 2016, 938 randomly selected adolescents (ages 11–17 years) who had been continuous residents of Nairobi from birth were invited to participate in the study. Standard clinic BP measurement was performed, followed by 24-hour ambulatory BP monitoring and arterial stiffness measurement using an Arteriograph24 (TensioMed Ltd., Budapest, Hungary) device. SCT status was determined using DNA genotyping in contemporaneously collected blood samples. Of the 938 adolescents invited to participate, 609 (65%) provided complete data for analysis. SCT was present in 103 (15%). Mean 24-hour systolic and diastolic BPs were 116 (standard deviation (SD), 11.5) mm Hg and 64 (SD, 7) mm Hg, respectively, in children with SCT and 117 (SD, 11.4) mm Hg and 64 (SD, 6.8) mm Hg, respectively, in non-SCT children. Mean pulse wave velocity (PWV) was 7.1 (SD, 0.8) m/second and 7.0 (SD, 0.8) m/second in SCT and non-SCT children, respectively. We observed no differences in PWV or in any clinic or ambulatory BP-derived measures between adolescents with and without SCT. These data suggest that SCT does not independently influence BP or PWV.
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影响因子：
2
作者：
Fagard, Robert H
通讯作者：
Fagard, Robert H
影响因子：
4.9
作者：
Octavio, Jose A.;Contreras, Jesus;Parati, Gianfranco
通讯作者：
Parati, Gianfranco
影响因子：
4.9
作者：
Horvath, Ivan G.;Nemeth, Adam;Cziraki, Attila
通讯作者：
Cziraki, Attila
影响因子：
2.6
作者：
Bayramoglu, Tunzale;Akkus, Oguz;Acarturk, Esmeray
通讯作者：
Acarturk, Esmeray
DOI：
10.1182/asheducation-2010.1.418
发表时间：
2010-12-01
影响因子：
3
作者：
Key, Nigel S.;Derebail, Vimal K.
通讯作者：
Derebail, Vimal K.