Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies
Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies
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DOI：
10.1016/s0142-9612(01)00336-2
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发表时间：
2002-05-01
期刊：
影响因子：
14
通讯作者：
Dumitriu, M
中科院分区：
文献类型：
--
作者：
Grynpas, MD;Pilliar, RM;Dumitriu, M
将通过重力烧结粒度范围为45-105、105-150和150 - 250 μ m的颗粒制成的聚磷酸钙（CPP）多孔棒（长6 mm，直径4 mm）植入新西兰白色兔股骨远端，初始体积百分比孔隙率为35-45%。在最初的实验中，四只兔子植入由粗颗粒（150 - 250微米）制成的杆在以下时间点的每一个被处死：2天，2周，6周和12周。在随后的实验中，10只兔子被植入通过烧结45-105 μ m颗粒制成的杆，另外10只兔子被植入通过使用105-150 μ m颗粒制成的杆。这些兔子在6周（5只兔子）和1年（5只兔子）时被处死。在两项实验的任何时间点，组织学上均未发现不良反应。这些实验表明，CPP大孔棒可以支持骨长入，并且在12周到1年之间，形成的骨量相当于在类似部位发现的自然骨量。CPP材料的降解与原始粒度成反比，并且最初（在前6周内）快速降解，之后降解速度减慢。总之，该材料似乎促进快速骨长入，并且可以通过适当选择起始粒度来定制以在体内以给定速率降解至声速。(C)2002爱思唯尔科技有限公司。保留所有权利。
Porous rods (6 mm in length and 4 mm in diameter) of calcium polyphosphate (CPP) made by gravity sintering of particles in the size ranges of 45-105, 105-150, and 150 250 mum and with initial volume percent porosity in the range of 35-45% were implanted in the distal femur of New Zealand white rabbits. In an initial experiment, four rabbits implanted with rods made from coarse particles (150 250 mum) were sacrificed at each of the following time points: 2 days, 2 weeks, 6 weeks and 12 weeks. In a subsequent experiment, 10 rabbits were implanted with rods made by sintering 45-105 mum particles and another 10 were made by using particles of 105-150 mum, These rabbits were sacrificed at 6 weeks (five rabbits) and 1 year (five rabbits). No adverse reaction was found histologically at any time point in either experiment. These experiments show that CPP macroporous rods can support bone ingrowth and that between 12 weeks and I year, the amount of bones formed is equivalent to the natural bone volume found at similar sites. The degradation of the CPP material is inversely proportional to the original particle size and is rapid initially (within the first 6 weeks) and slows down thereafter. In conclusion, this material seems to promote rapid bone ingrowth and can be tailored to degrade at a given rate in vivo to sonic degree through appropriate selection of the starting particle size. (C) 2002 Elsevier Science Ltd. All rights reserved.