Heart booster: A pericardial support device
Heart booster: A pericardial support device
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DOI：
10.1016/s0003-4975(99)00524-x
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发表时间：
1999-08-01
影响因子：
4.6
通讯作者：
Rosenberg, M
中科院分区：
文献类型：
--
作者：
Kung, RTV;Rosenberg, M
背景资料。充血性心力衰竭是一种普遍存在的疾病，困扰着数百万人。对于许多人来说，心包装置可以显著提高他们的生活质量，这种装置可以增加心输出量，而不会增加与直接血液接触相关的血栓栓塞症的风险。带有管状元件的心脏辅助装置被包裹在心脏周围，液体被泵入和泵出包裹，导致其周长收缩和扩张。这种收缩和放松的作用产生了心脏辅助，而不需要接触血液。通过体外表征和小牛体内实验，验证了该装置的特性。在体外，该装置包裹在半个心室上模拟左心室支持，在生理后负荷下的输出量为6.5%L/分钟。在小牛身上的活体研究表明，当该装置被激活时，心输出量和后负荷都会增加。这项研究首次展示了一种通过收缩和松弛方案提供心脏支持的装置，该装置包裹在心脏的外膜上。这种驱动方法的主要特点是有可能制造一种小型设备，用于无血液接触的植入。(C)1999年，由胸外科医生学会颁发。
Background. Congestive heart failure is a pervasive disease afflicting millions of people. For many, their quality of life can be significantly improved by a pericardial device that can enhance cardiac output without the added risk of thromboembolism associated with direct blood contact.Methods. A cardiac assist device with tubular elements is wrapped around the heart Fluid is pumped into and out of the wrap causing contraction and dilation of its circumference. This contracting and relaxing action generates cardiac assistance without the need to contact blood. In vitro characterization and in vivo studies in calves were conducted to demonstrate the characteristics of the device.Results. In vitro characterization with the device wrapped around one-half of a ventricle to simulate left ventricular support demonstrated outputs of 6.5 L/min at physiological afterloads. In vivo studies in calves demonstrated both cardiac output and afterload enhancements when the device is activated.Conclusions. This study provides a first demonstration of a device that provides cardiac support by a contraction and relaxation scheme with the device wrapped around the epicardium of the heart. The main feature of this actuation method is the potential for building a small device for implantation without blood contact. (C) 1999 by The Society of Thoracic Surgeons.