TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer's disease
TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer's disease
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DOI：
10.1007/s00702-006-0479-5
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发表时间：
2006-11-01
影响因子：
3.3
通讯作者：
Robinson, S. R.
中科院分区：
文献类型：
--
作者：
Edwards, M. M.;Robinson, S. R.
神经退行性疾病如阿尔茨海默病的特征在于星形胶质细胞蛋白质胶质细胞酸性蛋白（GFAP）和S100B的细胞内和细胞外浓度增加。本研究通过测量星形胶质细胞活力沿着暴露于这种细胞因子后GFAP和S100 B的细胞内和细胞外表达来检查肿瘤坏死因子α（TNF α）对这些变化的潜在贡献。虽然TNF α不影响星形胶质细胞的活力，细胞外的两种蛋白质的水平增加了三倍，相关的免疫细胞化学标记的减少。
Neurodegenerative disorders such as Alzheimer's disease are characterized by increased intracellular and extracellular concentrations of the astrocytic proteins glial fibrillary acidic protein (GFAP) and S100B. The present study examined the potential contribution of tumor necrosis factor alpha (TNF alpha) to these changes by measuring astrocyte viability along with the intracellular and extracellular expression of GFAP and S100B following exposure to this cytokine. Although TNF alpha did not affect astrocyte viability, the extracellular levels of both proteins were increased three-fold with associated reductions in immunocytochemical labeling.