Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome.
Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome.
复制标题
纤维肌痛的生物学和治疗。纤维肌痛综合征的遗传方面。
DOI：
10.1186/ar2005
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发表时间：
2006
影响因子：
4.9
通讯作者：
Sarzi-Puttini, Piercarlo
中科院分区：
文献类型：
--
作者：
Buskila, Dan;Sarzi-Puttini, Piercarlo
遗传和环境因素可能在纤维肌痛综合征（FMS）和其他相关综合征的发病机制中发挥作用。在FMS患者的家庭中，FMS具有较高的聚集性。遗传方式尚不清楚，但很可能是多基因的。有证据表明，多巴胺能，多巴胺能和儿茶酚胺能系统的基因多态性在FMS的病因学中发挥作用。这些多态性不是FMS的特异性，并且与其他功能性躯体疾病和抑郁症相关。未来FMS和相关疾病领域的遗传学研究应在更大的患者队列和种族匹配的对照组中进行。
Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems play a role in the etiology of FMS. These polymorphisms are not specific for FMS and are associated with other functional somatic disorders and depression. Future genetic studies in the field of FMS and related conditions should be conducted in larger cohorts of patients and ethnically matched control groups.